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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-Ppargc1a)1Dpk
transgene insertion 1, Daniel P Kelly
MGI:4429485
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ay/a
Tg(tetO-Ppargc1a)1Dpk/0
Tg(Tyr-rtTA)37Lc/0
involves: FVB MGI:6259414
cx2
Tg(Myh6-rtTA)8585Jam/0
Tg(tetO-Ppargc1a)1Dpk/0
involves: FVB/N * FVB/NTac MGI:4429501


Genotype
MGI:6259414
cx1
Allelic
Composition
Ay/a
Tg(tetO-Ppargc1a)1Dpk/0
Tg(Tyr-rtTA)37Lc/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (459 available)
Ay mutation (12 available); any a mutation (459 available)
Tg(tetO-Ppargc1a)1Dpk mutation (1 available)
Tg(Tyr-rtTA)37Lc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of Ay/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black
• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to Ay/a Tg(Tyr-rtTA)37Lc/0 mice

integument
• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of Ay/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black
• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to Ay/a Tg(Tyr-rtTA)37Lc/0 mice




Genotype
MGI:4429501
cx2
Allelic
Composition
Tg(Myh6-rtTA)8585Jam/0
Tg(tetO-Ppargc1a)1Dpk/0
Genetic
Background
involves: FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-rtTA)8585Jam mutation (1 available)
Tg(tetO-Ppargc1a)1Dpk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• following doxycycline treatment, adult mice exhibit eccentric hypertrophy unlike in wild-type mice

cardiovascular system
• following doxycycline treatment of neonates, myofibril mitochondria density is increased 3.5-fold compared with wild-type myofibrils due to increased biogenesis
• doxycycline-treated adult mice exhibit an increased in mitochondrial biogenesis in myofibrils compared with wild-type mice but not to the extent observed in doxycycline treated neonates
• however, removal of doxycycline restores normal mitochondria
• following doxycycline treatment, adult mice exhibit eccentric hypertrophy unlike in wild-type mice
• 2 week after doxycycline treatment, adult mice exhibit increased end-diastolic and end-systolic left ventricle diameter and a mild increase in left ventricular wall thickness compared with wild-type mice
• following doxycycline treatment of adult mice
• following doxycycline treatment of adult mice
• following doxycycline treatment, adult mice exhibit decreased fractional shortening compared with wild-type mice
• however, removal of doxycycline restores cardiac muscle contractility
• following doxycycline treatment of adult mice
• following removal of doxycycline
• following induction of expression with doxycycline, adult mice exhibit reversible cardiomyopathy unlike wild-type mice
• however, no increase in cardiac cell apoptosis is observed

cellular
• following doxycycline treatment, adult mice exhibit an increase in mitochondrial number along with mitochondrial ultrastructural abnormalities unlike in wild-type mice
• following doxycycline treatment of neonates, myofibril mitochondria density is increased 3.5-fold compared with wild-type myofibrils due to increased biogenesis
• doxycycline-treated adult mice exhibit an increased in mitochondrial biogenesis in myofibrils compared with wild-type mice but not to the extent observed in doxycycline treated neonates
• however, removal of doxycycline restores normal mitochondria

muscle
• following doxycycline treatment of neonates, myofibril mitochondria density is increased 3.5-fold compared with wild-type myofibrils due to increased biogenesis
• doxycycline-treated adult mice exhibit an increased in mitochondrial biogenesis in myofibrils compared with wild-type mice but not to the extent observed in doxycycline treated neonates
• however, removal of doxycycline restores normal mitochondria
• following doxycycline treatment, adult mice exhibit decreased fractional shortening compared with wild-type mice
• however, removal of doxycycline restores cardiac muscle contractility
• following induction of expression with doxycycline, adult mice exhibit reversible cardiomyopathy unlike wild-type mice
• however, no increase in cardiac cell apoptosis is observed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiomyopathy DOID:0050700 J:96614
congestive heart failure DOID:6000 J:96614





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory