Phenotypes associated with this allele

• Allele Symbol: Agr2^tm1.2Lpkn
• Allele Name: targeted mutation 1.2, Steven M Lipkin
• Allele ID: MGI:4421689
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agr2^tm1.2Lpkn/Agr2^tm1.2Lpkn	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4421702

Genotype
MGI:4421702

hm1

• Allelic Composition: Agr2^tm1.2Lpkn/Agr2^tm1.2Lpkn
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:156704 )

• mice lack normal goblet cells unlike wild-type mice

abnormal enterocyte morphology ( J:156704 )

• cells containing large, dense eosinophilic granules are abnormally positioned in the colonic villi

abnormal large intestine crypts of Lieberkuhn morphology ( J:156704 )

• mice exhibit crypt hyperplasia unlike wild-type mice

increased Paneth cell number ( J:156704 )

• the Paneth cell compartment is expanded compared to in wild-type mice

colitis ( J:156704 )

• mice exhibit mixed acute and chronic inflammatory infiltrate expanding the isolated lymphoid follicles and lamina propria unlike in wild-type mice

ileum inflammation ( J:156704 )

• most severe in the terminal ileum

immune system

colitis ( J:156704 )

• mice exhibit mixed acute and chronic inflammatory infiltrate expanding the isolated lymphoid follicles and lamina propria unlike in wild-type mice

ileum inflammation ( J:156704 )

• most severe in the terminal ileum

abnormal Peyer's patch follicle morphology ( J:156704 )

• mice exhibit hyperplasia of the Peyer's patches unlike in wild-type mice

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:156704 )

• mice exhibit crypt hyperplasia unlike wild-type mice

increased Paneth cell number ( J:156704 )

• the Paneth cell compartment is expanded compared to in wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:156704 )

• mice lack normal goblet cells unlike wild-type mice