Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation
(0 available);
any
Cd74 mutation
(33 available)
Lmo2tm2(cre)Thr mutation
(0 available);
any
Lmo2 mutation
(31 available)
Smim3tm1Anjm mutation
(0 available);
any
Smim3 mutation
(9 available)
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hematopoietic system
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• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow
• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow
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• a decrease in erythroid colony-forming units in the bone marrow
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• there are a reduced numbers of circulating red blood cells
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• in bone marrow and spleen
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• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow
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skeleton
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation
(0 available);
any
Cd74 mutation
(33 available)
Lmo2tm2(cre)Thr mutation
(0 available);
any
Lmo2 mutation
(31 available)
Smim3tm1Anjm mutation
(0 available);
any
Smim3 mutation
(9 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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hematopoietic system
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• a decrease in granulocyte/macrophage colony-forming units in bone marrow
• by flow cytometry, there is a reduction in granulocyte-monocyte progenitors in the bone marrow
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• as measured by erythroid colony-forming units in bone marrow
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• a reduced number of circulating red blood cells
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• in bone marrow and spleen
|
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• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors in the bone marrow
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation
(0 available);
any
Cd74 mutation
(33 available)
Lmo2tm2(cre)Thr mutation
(0 available);
any
Lmo2 mutation
(31 available)
Smim3tm1Anjm mutation
(0 available);
any
Smim3 mutation
(9 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
|
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hematopoietic system
N |
• absence of Trp53 expression completely rescues hematopoetic defects seen in mutant mice wild-type for Trp53
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation
(0 available);
any
Cd74 mutation
(33 available)
Lmo2tm2(cre)Thr mutation
(0 available);
any
Lmo2 mutation
(31 available)
Smim3tm1Anjm mutation
(0 available);
any
Smim3 mutation
(9 available)
|
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hematopoietic system
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• an elevated proportion of mast cells in the bone marrow
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• a reduced number of cells are flushed from the femurs
• histological bone marrow sections have mild to high hypocellularity
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• decreased granulocyte/macrophage colony-forming units
• by flow cytometry, a reduction in granulocyte-monocyte progenitors in the bone marrow
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• monolobulated megakaryocytes in the bone marrow
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• a decreased number of erythroid colony-forming units
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• a decreased number of megakaryocyte colony-forming units
• considerably fewer in the bone marrow by flow cytometry
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• pencil shaped cells are present in blood smears
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• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage
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• prominent erythroid dysplasia, dyserythropoiesis
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• increase in the mean red blood cell distribution width
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• in bone marrow and peripheral blood
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• total granulocyte numbers are lower in the blood
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• an elevated proportion of mast cells in the bone marrow
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• in bone marrow and spleen
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• by flow cytometry, a reduction in megakaryocytic-erythroid progenitors in the bone marrow
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immune system
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• total granulocyte numbers are lower in the blood
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• an elevated proportion of mast cells in the bone marrow
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation
(0 available);
any
Cd74 mutation
(33 available)
Smim3tm1Anjm mutation
(0 available);
any
Smim3 mutation
(9 available)
|
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hematopoietic system
N |
• no abnormal phenotype associated with the development of red blood cells (RBCs) or platelets
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