• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow

• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors and granulocyte-monocyte progenitors in the bone marrow

• there are a reduced numbers of circulating red blood cells

• a decrease in erythroid colony-forming units in the bone marrow

• bone marrow dysplasia

• in bone marrow and spleen

• a decrease in granulocyte/macrophage colony-forming units in bone marrow

• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors and granulocyte-monocyte progenitors in the bone marrow

• a reduced number of circulating red blood cells

• as measured by erythroid colony-forming units in bone marrow

• in bone marrow and spleen

• absence of Trp53 expression completely rescues hematopoetic defects seen in mutant mice wild-type for Trp53 (J:155870)

• pencil shaped cells are present in blood smears

• by flow cytometry, a reduction in megakaryocytic-erythroid and granulocyte-monocyte progenitors in the bone marrow

• decreased granulocyte/macrophage colony-forming units

• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage

• prominent erythroid dysplasia, dyserythropoiesis

• increase in the mean red blood cell distribution width

• in bone marrow and peripheral blood

• a decreased number of erythroid colony-forming units

• total granulocyte numbers are lower in the blood

• in the blood

• modest

• an elevated proportion of mast cells in the bone marrow

• an elevated proportion of mast cells in the bone marrow

• a reduced number of cells are flushed from the femurs

• histological bone marrow sections have mild to high hypocellularity

• a decreased number of megakaryocyte colony-forming units

• considerably fewer in the bone marrow by flow cytometry

• monolobulated megakaryocytes in the bone marrow

• in bone marrow and spleen

• total granulocyte numbers are lower in the blood

• in the blood

• an elevated proportion of mast cells in the bone marrow

• no abnormal phenotype associated with the development of red blood cells (RBCs) or platelets (J:155870)