Mouse Genome Informatics
cn1
    Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+

involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow
• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors and granulocyte-monocyte progenitors in the bone marrow
• there are a reduced numbers of circulating red blood cells
• a decrease in erythroid colony-forming units in the bone marrow
• in bone marrow and spleen

Mouse Models of Human Disease
OMIM IDRef(s)
Chromosome 5q Deletion Syndrome 153550 J:155870


Mouse Genome Informatics
cn2
    Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53+

involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• a decrease in granulocyte/macrophage colony-forming units in bone marrow
• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors and granulocyte-monocyte progenitors in the bone marrow
• a reduced number of circulating red blood cells
• as measured by erythroid colony-forming units in bone marrow
• in bone marrow and spleen


Mouse Genome Informatics
cn3
    Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53tm1Brd

involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
N
• absence of Trp53 expression completely rescues hematopoetic defects seen in mutant mice wild-type for Trp53 (J:155870)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Chromosome 5q Deletion Syndrome 153550 J:155870


Mouse Genome Informatics
cn4
    Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• pencil shaped cells are present in blood smears
• by flow cytometry, a reduction in megakaryocytic-erythroid and granulocyte-monocyte progenitors in the bone marrow
• decreased granulocyte/macrophage colony-forming units
• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage
• prominent erythroid dysplasia, dyserythropoiesis
• increase in the mean red blood cell distribution width
• in bone marrow and peripheral blood
• a decreased number of erythroid colony-forming units
• total granulocyte numbers are lower in the blood
• an elevated proportion of mast cells in the bone marrow
• an elevated proportion of mast cells in the bone marrow
• a reduced number of cells are flushed from the femurs
• histological bone marrow sections have mild to high hypocellularity
• a decreased number of megakaryocyte colony-forming units
• considerably fewer in the bone marrow by flow cytometry
• monolobulated megakaryocytes in the bone marrow
• in bone marrow and spleen

immune system
• total granulocyte numbers are lower in the blood
• an elevated proportion of mast cells in the bone marrow

Mouse Models of Human Disease
OMIM IDRef(s)
Chromosome 5q Deletion Syndrome 153550 J:155870


Mouse Genome Informatics
cx5
    Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
N
• no abnormal phenotype associated with the development of red blood cells (RBCs) or platelets (J:155870)