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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smim3tm1Anjm
targeted mutation 1, Andrew N J McKenzie
MGI:4421686
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4421776
cn2
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4421779
cn3
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53tm1Brd
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4421780
cn4
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
involves: 129P2/OlaHsd * C57BL/6 MGI:4421775
cx5
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
involves: 129P2/OlaHsd * C57BL/6 MGI:4421699


Genotype
MGI:4421776
cn1
Allelic
Composition
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (18 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (14 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow
• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow
• a decrease in erythroid colony-forming units in the bone marrow
• there are a reduced numbers of circulating red blood cells
• in bone marrow and spleen
• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow

skeleton
• bone marrow dysplasia

Mouse Models of Human Disease
OMIM ID Ref(s)
Chromosome 5q Deletion Syndrome 153550 J:155870




Genotype
MGI:4421779
cn2
Allelic
Composition
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (18 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (14 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (12 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a decrease in granulocyte/macrophage colony-forming units in bone marrow
• by flow cytometry, there is a reduction in granulocyte-monocyte progenitors in the bone marrow
• as measured by erythroid colony-forming units in bone marrow
• a reduced number of circulating red blood cells
• in bone marrow and spleen
• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors in the bone marrow




Genotype
MGI:4421780
cn3
Allelic
Composition
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (18 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (14 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (12 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• absence of Trp53 expression completely rescues hematopoetic defects seen in mutant mice wild-type for Trp53

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Chromosome 5q Deletion Syndrome 153550 J:155870




Genotype
MGI:4421775
cn4
Allelic
Composition
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (18 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (14 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• an elevated proportion of mast cells in the bone marrow
• a reduced number of cells are flushed from the femurs
• histological bone marrow sections have mild to high hypocellularity
• decreased granulocyte/macrophage colony-forming units
• by flow cytometry, a reduction in granulocyte-monocyte progenitors in the bone marrow
• a decreased number of erythroid colony-forming units
• a decreased number of megakaryocyte colony-forming units
• considerably fewer in the bone marrow by flow cytometry
• monolobulated megakaryocytes in the bone marrow
• pencil shaped cells are present in blood smears
• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage
• prominent erythroid dysplasia, dyserythropoiesis
• increase in the mean red blood cell distribution width
• in bone marrow and peripheral blood
• total granulocyte numbers are lower in the blood
• an elevated proportion of mast cells in the bone marrow
• modest
• in bone marrow and spleen
• by flow cytometry, a reduction in megakaryocytic-erythroid progenitors in the bone marrow

immune system
• total granulocyte numbers are lower in the blood
• an elevated proportion of mast cells in the bone marrow

Mouse Models of Human Disease
OMIM ID Ref(s)
Chromosome 5q Deletion Syndrome 153550 J:155870




Genotype
MGI:4421699
cx5
Allelic
Composition
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (18 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• no abnormal phenotype associated with the development of red blood cells (RBCs) or platelets





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory