Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm2Stl mutation
(1 available);
any
Grin1 mutation
(64 available)
Tg(Ppp1r2-cre)4127Nkza mutation
(1 available)
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behavior/neurological
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N |
• adult mice (25-29 weeks of age) do not show behavioral deficits and display normal social recognition
• mice at more than 32 weeks of age do not deficits in nest building behavior
• mice do not show anxiety-like behaviors
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nervous system
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N |
• mice display normal prepulse inhibition of the auditory startle reflex
• no differences in mean firing rates or cross-correlation values of pyramidal neurons are detected relative to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Yql mutation
(1 available);
any
Grin1 mutation
(64 available)
Tg(Ppp1r2-cre)4127Nkza mutation
(1 available)
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growth/size/body
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N |
• male mice (8-18 weeks) single-housed for 1 week or longer show no abnormalities in growth rate
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behavior/neurological
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N |
• male mice (8-18 weeks) single-housed for 1 week or longer show no impairment in pain, sensitivity or motor coordination
• no locomotor abnormality is apparent at 9-10 weeks of age
• single-housed mice perform normally in a forced swim test at 12-15 weeks, displaying no depressive-like behavior
• spatial acuity is normal
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• in a Y-maze test, mutants show a reduction in alternatation down to chance levels relative to controls which demonstrate reliable alternation
• administration of risperidone for 3 weeks alleviate the observed deficit
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• in a 2 bottle saccharine test, mice receiving 8 weeks of social isolation starting at 8 weeks of age show a decreased preference for sweet solutions, but total liquid intake is unchanged compared to controls
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• in an elevated plus maze test, group-housed mice display anxiety-like behavior at 16 weeks of age; single-housed animals show social isolation-induced stress and show anxiety-like behavior earlier, at 8 weeks of age
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• animals spend significantly less time exploring the center area of an open field
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• novelty-induced hyperlocomotion is prominent during the first 3 minutes of spontaneous exploration in open-field test
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• mutants older than 12 weeks display definite deficit in nest-building behavior; mice that were group-housed until 16 weeks of age show a milder nest-building deficit
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• breeding efficiency is significantly decreased in males older than 12 weeks that had been socially isolated from 7 weeks of age
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• when presented with a 4-week old stimulus male, 12-week old mutants do not investigate the stimulus mouse during the initial 1-minute presentation, which may indicate enhanced anxiety
• increased social investigation toward the novel animal is exhibited after the second trial (presentation) and this is maintained in subsequent trials without habituation, in contrast to control mice which show decreased interest in the stimulus animal in subsequent trials
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nervous system
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• putative pyramidal neurons from 13-14 week old mice show increased mean firing rates and decreased cross-correlation with nearby neurons compared to controls
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• 10-12 week old mice that were single-housed show an impaired prepulse inhibition of the auditory startle reflex, although the reflex amplitude is normal; a similar deficit is observed in age-matched group-housed mutants
• defects are partially ameliorated by risperidone
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hearing/vestibular/ear
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N |
• male mice (8-18 weeks) single-housed for 1 week or longer show no impairment in auditory function
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homeostasis/metabolism
vision/eye
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N |
• male mice (8-18 weeks) single-housed for 1 week or longer show no impairment in visual function
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Analysis Tools