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Allele Symbol Allele Name Allele ID |
Acantm1(cre/ERT2)Crm targeted mutation 1, Benoit de Crombrugghe MGI:4420223 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice injected with tamoxifen at P28 or P35 form large osteochondromas along synchondroses in the cranial base and along growth plates of long bones by 6-8 weeks after injection
• systemic treatment of tamoxifen-injected with mice a BMP signaling antagonist, LDN-193189 reduces osteochondroma development and growth
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• mice injected with tamoxifen at P28 or P35 form large osteochondromas along synchondroses in the cranial base and along growth plates of long bones by 6-8 weeks after injection
• systemic treatment of tamoxifen-injected with mice a BMP signaling antagonist, LDN-193189 reduces osteochondroma development and growth
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hereditary multiple exostoses | DOID:206 |
OMIM:133700 OMIM:133701 OMIM:600209 |
J:242977 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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