All Phenotypes Nhlrc2<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nhlrc2^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4419640

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nhlrc2^{tm1a(KOMP)Wtsi}/Nhlrc2^{tm1a(KOMP)Wtsi}	C57BL/6N-Nhlrc2^{tm1a(KOMP)Wtsi}/Wtsi	MGI:5767740
ht2	Nhlrc2^em1Rhtl/Nhlrc2^{tm1a(KOMP)Wtsi}	C57BL/6N-Nhlrc2^em1Rhtl Nhlrc2^{tm1a(KOMP)Wtsi}	MGI:6510815

Allelic Composition	Nhlrc2^{tm1a(KOMP)Wtsi}/Nhlrc2^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6N-Nhlrc2^{tm1a(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0393_4_F01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlrc2^{tm1a(KOMP)Wtsi} mutation (1 available); any Nhlrc2 mutation (20 available)

Data Sources

IMPC Data for Nhlrc2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Allelic Composition	Nhlrc2^em1Rhtl/Nhlrc2^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6N-Nhlrc2^em1Rhtl Nhlrc2^{tm1a(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlrc2^em1Rhtl mutation (0 available); any Nhlrc2 mutation (20 available)
Nhlrc2^{tm1a(KOMP)Wtsi} mutation (1 available); any Nhlrc2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:299152 )

N	• normal embryonic development; normal E13.5 embryos

growth/size/body

growth/size/body region phenotype ( J:299152 )

N	• normal growth

hematopoietic system

hematopoietic system phenotype ( J:299152 )

N	• normal hemoglobin and hematocrit values

liver/biliary system

liver/biliary system phenotype ( J:299152 )

N	• normal liver histology (no fibrosis)

nervous system

nervous system phenotype ( J:299152 )

N	• normal brain morphology (no atrophy) and normal hippocampus and cerebellum histology • normal in vitro growth of neuronal precursor cells (NPCs) isolated from E13.5 embryos

reproductive system

reproductive system phenotype ( J:299152 )

• fertile

respiratory system

respiratory system phenotype ( J:299152 )

N	• normal lung histology (no fibrosis)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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