Phenotypes associated with this allele

• Allele Symbol: Nhlrc2^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4419640
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nhlrc2^tm1a(KOMP)Wtsi/Nhlrc2^tm1a(KOMP)Wtsi	C57BL/6N-A^tm1Brd Nhlrc2^tm1a(KOMP)Wtsi/WtsiOulu	MGI:7277685
hm2	Nhlrc2^tm1a(KOMP)Wtsi/Nhlrc2^tm1a(KOMP)Wtsi	C57BL/6N-Nhlrc2^tm1a(KOMP)Wtsi/Wtsi	MGI:5767740
ht3	Nhlrc2^em1Rhtl/Nhlrc2^tm1a(KOMP)Wtsi	C57BL/6N-Nhlrc2^em1Rhtl Nhlrc2^tm1a(KOMP)Wtsi	MGI:6510815

Genotype
MGI:7277685

hm1

• Allelic Composition: Nhlrc2^{tm1a(KOMP)Wtsi}/Nhlrc2^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-A^tm1Brd Nhlrc2^{tm1a(KOMP)Wtsi}/WtsiOulu
• Cell Lines: EPD0393_4_F01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:324126 )

• all mice die prior to E9.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:324126 )

• few mice are present at E8.5

embryo

failure to gastrulate ( J:324126 )

• no defined internal structures at E7.5 with lack of organized mesoderm and ectoderm layers, allantois, amnion, chorion, and embryonic structures

embryonic growth retardation ( J:324126 )

• developmentally arrested or even degenerating at E7.5

absent allantois ( J:324126 )

• at E7.5

absent amnion ( J:324126 )

• at E7.5

absent chorion ( J:324126 )

• at E7.5

growth/size/body

embryonic growth retardation ( J:324126 )

• developmentally arrested or even degenerating at E7.5

Genotype
MGI:5767740

hm2

• Allelic Composition: Nhlrc2^{tm1a(KOMP)Wtsi}/Nhlrc2^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Nhlrc2^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0393_4_F01

Data Sources

IMPC Data for Nhlrc2

embryo

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:6510815

ht3

• Allelic Composition: Nhlrc2^em1Rhtl/Nhlrc2^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Nhlrc2^em1Rhtl Nhlrc2^{tm1a(KOMP)Wtsi}

embryo

embryo phenotype ( J:299152 )

N • normal embryonic development; normal E13.5 embryos

growth/size/body

growth/size/body region phenotype ( J:299152 )

N • normal growth

hematopoietic system

hematopoietic system phenotype ( J:299152 )

N • normal hemoglobin and hematocrit values

liver/biliary system

liver/biliary system phenotype ( J:299152 )

N • normal liver histology (no fibrosis)

nervous system

nervous system phenotype ( J:299152 )

N • normal brain morphology (no atrophy) and normal hippocampus and cerebellum histology

N • normal in vitro growth of neuronal precursor cells (NPCs) isolated from E13.5 embryos

reproductive system

reproductive system phenotype ( J:299152 )

N • fertile

respiratory system

respiratory system phenotype ( J:299152 )

N • normal lung histology (no fibrosis)