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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nhlrc2tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4419640
Summary 2 genotypes


Genotype
MGI:5767740
hm1
Allelic
Composition
Nhlrc2tm1a(KOMP)Wtsi/Nhlrc2tm1a(KOMP)Wtsi
Genetic
Background
C57BL/6N-Nhlrc2tm1a(KOMP)Wtsi/Wtsi
Cell Lines EPD0393_4_F01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlrc2tm1a(KOMP)Wtsi mutation (1 available); any Nhlrc2 mutation (20 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• small or absent trophoblast compartment
• biased differentiation (diploid/polyploid trophoblast)

mortality/aging




Genotype
MGI:6510815
ht2
Allelic
Composition
Nhlrc2em1Rhtl/Nhlrc2tm1a(KOMP)Wtsi
Genetic
Background
C57BL/6N-Nhlrc2em1Rhtl Nhlrc2tm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlrc2em1Rhtl mutation (0 available); any Nhlrc2 mutation (20 available)
Nhlrc2tm1a(KOMP)Wtsi mutation (1 available); any Nhlrc2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• normal embryonic development; normal E13.5 embryos

growth/size/body

hematopoietic system
N
• normal hemoglobin and hematocrit values

liver/biliary system
N
• normal liver histology (no fibrosis)

nervous system
N
• normal brain morphology (no atrophy) and normal hippocampus and cerebellum histology
• normal in vitro growth of neuronal precursor cells (NPCs) isolated from E13.5 embryos

reproductive system

respiratory system
N
• normal lung histology (no fibrosis)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory