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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ehmt1tm1.1Tara
targeted mutation 1.1, Alexander Tarakhovsky
MGI:4418563
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Myf5tm3(cre)Sor/Myf5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:6105943
cn2
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Camk2a-cre)2Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418570
cn3
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Tg(Camk2a-cre)2Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418566
cn4
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Tg(Adipoq-cre)1Evdr/0
involves: 129P2/OlaHsd * FVB/NJ MGI:5910281


Genotype
MGI:6105943
cn1
Allelic
Composition
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Myf5tm3(cre)Sor/Myf5+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.1Tara mutation (0 available); any Ehmt1 mutation (90 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• at E18.5 and P1




Genotype
MGI:4418570
cn2
Allelic
Composition
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Camk2a-cre)2Gsc/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.1Tara mutation (0 available); any Ehmt1 mutation (90 available)
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (55 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• travel significantly less than control mice in a new environment
• reduction in vertical episodes in a new environment
• travel significantly less than control mice in a new environment




Genotype
MGI:4418566
cn3
Allelic
Composition
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Tg(Camk2a-cre)2Gsc/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.1Tara mutation (0 available); any Ehmt1 mutation (90 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• the specific neuronal cell architecture in the striatum and the hippocampus is not altered

behavior/neurological
• almost completely lack a preference for sucrose
• do not remember their negative experience
• do not remember their negative experience
• starting around 6-8 weeks of age in an open field make fewer total arm entries in an elevated plus maze
• almost completely lack a preference for sucrose
• make more entries into and spend more time in open arms in an elevated plus maze
• slightly improved performance in some trials during standard accelerated rotarod analysis
• in a new environment
• in a new environment

growth/size/body
• almost double the body weight as compared to controls by 5-6 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Kleefstra syndrome 1 DOID:0060352 OMIM:610253
J:155739




Genotype
MGI:5910281
cn4
Allelic
Composition
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Tg(Adipoq-cre)1Evdr/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.1Tara mutation (0 available); any Ehmt1 mutation (90 available)
Tg(Adipoq-cre)1Evdr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• reduced fatty-acid oxidation capacity in brown adipose tissue
• temperature drop in cold-exposed mice
• at fasted and glucose-stimulated states
• temperature drop in cold-exposed mice
• loss of induced increase in oxygen consumption after administering CL316,243

adipose tissue
• reduced fatty-acid oxidation capacity and fatty acid uptake in brown adipose tissue

growth/size/body
• without a change in food intake

liver/biliary system
• higher amounts of lipids

cellular
• reduced fatty-acid oxidation capacity in brown adipose tissue





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory