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hm1
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Phox2btm3Jbr/Phox2btm3Jbr
involves: 129S2/SvPas * C57BL/6 * DBA/2 |
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cn2
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Isl1tm1(cre)Tmj/Isl1+ Phox2btm3Jbr/Phox2btm3Jbr involves: 129S2/SvPas * 129X1/SvJ |
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• fails to form, on six sides out of eight, in four embryos
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• missing, on five sides out of six, in three embryos
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cn3
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Phox2btm3Jbr/Phox2btm3Jbr Isl1tm1(cre)Tmj/Isl1+ involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 |
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• 1 week after birth, few mice are still alive
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• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
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• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice
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• surviving mice are smaller than wild-type mice
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• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
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cn4
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Phox2btm3Jbr/Phox2btm3Jbr Tg(Pgk1-cre)1Lni/0 involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2 |
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cn5
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Phox2btm3Jbr/Phox2btm3Jbr Tg(Pou3f4-cre)32Cren/0 involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 |
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cn6
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Phox2btm3Jbr/Phox2btm3Jbr Egr2tm2(cre)Pch/Egr2+ involves: 129S2/SvPas * C57BL/6 * DBA/2 |
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• 1 week after birth, mice are dead
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• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
|
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• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice
|
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• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
|
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cn7
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Phox2btm3Jbr/Phox2btm3Jbr Tg(Wnt1-cre)11Rth/0 involves: 129S2/SvPas * C57BL/6J * CBA/J |
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• absence of all head parasympathetic ganglia
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cn8
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Phox2btm3Jbr/Phox2btm3Jbr Tg(Pou3f4-cre)32Cren/0 involves: 129S2/SvPas * CD-1 |
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| N |
• despite the absence of visceral or branchial motoneurons, the main trunk of the facial nerve is present
(J:157532)
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• visceromotor neurons are not produced
• absence of visceral or branchial motoneurons
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