All Phenotypes Phox2b<tm3.1Jbr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Phox2b^tm3.1Jbr
targeted mutation 3.1, Jean-Francois Brunet
MGI:4418265

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:4418301
cn2	Isl1^tm1(cre)Tmj/Isl1⁺ Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr	involves: 129S2/SvPas * 129X1/SvJ	MGI:4438214
cn3	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Isl1^tm1(cre)Tmj/Isl1⁺	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4418306
cn4	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Tg(Pgk1-cre)1Lni/0	involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2	MGI:4418303
cn5	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Tg(Pou3f4-cre)32Cren/0	involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2	MGI:4418304
cn6	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Egr2^tm2(cre)Pch/Egr2⁺	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:4418307
cn7	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S2/SvPas * C57BL/6J * CBA/J	MGI:4438210
cn8	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Tg(Pou3f4-cre)32Cren/0	involves: 129S2/SvPas * CD-1	MGI:4438213

Allelic Composition	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm3.1Jbr mutation (2 available); any Phox2b mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:155885 )

• mice exhibit no obvious phenotype

Allelic Composition	Isl1^tm1(cre)Tmj/Isl1⁺ Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (33 available)
Phox2b^tm3.1Jbr mutation (2 available); any Phox2b mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal pterygopalatine ganglion morphology ( J:157532 )

• fails to form, on six sides out of eight, in four embryos

absent petrosal ganglion ( J:157532 )

• missing, on five sides out of six, in three embryos

Allelic Composition	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Isl1^tm1(cre)Tmj/Isl1⁺
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:155885 )

• 1 week after birth, few mice are still alive

nervous system

abnormal neuron differentiation ( J:155885 )

• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice

• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice

abnormal neuron physiology ( J:155885 )

• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice

• rhythmic phrenic discharges are less frequent than in wild-type mice

• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice

growth/size/body

decreased body size ( J:155885 )

• surviving mice are smaller than wild-type mice

cellular

abnormal neuron differentiation ( J:155885 )

• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice

• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice

Allelic Composition	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm3.1Jbr mutation (2 available); any Phox2b mutation (25 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:155885 )

• mice die at E13.5

Allelic Composition	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Tg(Pou3f4-cre)32Cren/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm3.1Jbr mutation (2 available); any Phox2b mutation (25 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system morphology ( J:155885 )

• mice exhibit phenotypic defects observed in Phox2b^tm1Jbr homozygotes

Allelic Composition	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Egr2^tm2(cre)Pch/Egr2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2^tm2(cre)Pch mutation (2 available); any Egr2 mutation (31 available)
Phox2b^tm3.1Jbr mutation (2 available); any Phox2b mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:155885 )

• 1 week after birth, mice are dead

nervous system

abnormal neuron differentiation ( J:155885 )

• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice

abnormal neuron physiology ( J:155885 )

• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice

• rhythmic phrenic discharges are less frequent than in wild-type mice

• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice

cellular

abnormal neuron differentiation ( J:155885 )

• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice

Allelic Composition	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Phox2b^tm3.1Jbr mutation (2 available); any Phox2b mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal parasympathetic ganglion morphology ( J:157532 )

• absence of all head parasympathetic ganglia

Allelic Composition	Phox2b^tm3.1Jbr/Phox2b^tm3.1Jbr Tg(Pou3f4-cre)32Cren/0
Genetic Background	involves: 129S2/SvPas * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm3.1Jbr mutation (2 available); any Phox2b mutation (25 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:157532 )

N	• despite the absence of visceral or branchial motoneurons, the main trunk of the facial nerve is present

abnormal motor neuron morphology ( J:157532 )

• visceromotor neurons are not produced

• absence of visceral or branchial motoneurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23