Mouse Genome Informatics
hm1
    Phox2btm3Jbr/Phox2btm3Jbr
involves: 129S2/SvPas * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mice exhibit no obvious phenotype


Mouse Genome Informatics
cn2
    Isl1tm1(cre)Tmj/Isl1+
Phox2btm3Jbr/Phox2btm3Jbr

involves: 129S2/SvPas * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• fails to form, on six sides out of eight, in four embryos
• missing, on five sides out of six, in three embryos


Mouse Genome Informatics
cn3
    Phox2btm3Jbr/Phox2btm3Jbr
Isl1tm1(cre)Tmj/Isl1+

involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 1 week after birth, few mice are still alive

nervous system
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice

growth/size
• surviving mice are smaller than wild-type mice

cellular
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice


Mouse Genome Informatics
cn4
    Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pgk1-cre)1Lni/0

involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging


Mouse Genome Informatics
cn5
    Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pou3f4-cre)32Cren/0

involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice exhibit phenotypic defects observed in Phox2btm1Jbr homozygotes


Mouse Genome Informatics
cn6
    Phox2btm3Jbr/Phox2btm3Jbr
Egr2tm2(cre)Pch/Egr2+

involves: 129S2/SvPas * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 1 week after birth, mice are dead

nervous system
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice

cellular
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice


Mouse Genome Informatics
cn7
    Phox2btm3Jbr/Phox2btm3Jbr
Tg(Wnt1-cre)11Rth/0

involves: 129S2/SvPas * C57BL/6J * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• absence of all head parasympathetic ganglia


Mouse Genome Informatics
cn8
    Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pou3f4-cre)32Cren/0

involves: 129S2/SvPas * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• despite the absence of visceral or branchial motoneurons, the main trunk of the facial nerve is present (J:157532)
• visceromotor neurons are not produced
• absence of visceral or branchial motoneurons