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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Phox2btm3Jbr
targeted mutation 3, Jean-Francois Brunet
MGI:4418265
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Phox2btm3Jbr/Phox2btm3Jbr involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:4418301
cn2
Isl1tm1(cre)Tmj/Isl1+
Phox2btm3Jbr/Phox2btm3Jbr
involves: 129S2/SvPas * 129X1/SvJ MGI:4438214
cn3
Phox2btm3Jbr/Phox2btm3Jbr
Isl1tm1(cre)Tmj/Isl1+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4418306
cn4
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2 MGI:4418303
cn5
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 MGI:4418304
cn6
Phox2btm3Jbr/Phox2btm3Jbr
Egr2tm2(cre)Pch/Egr2+
involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:4418307
cn7
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Wnt1-cre)11Rth/0
involves: 129S2/SvPas * C57BL/6J * CBA/J MGI:4438210
cn8
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * CD-1 MGI:4438213


Genotype
MGI:4418301
hm1
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no obvious phenotype (J:155885)
• mice exhibit no obvious phenotype (J:155885)




Genotype
MGI:4438214
cn2
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Phox2btm3Jbr/Phox2btm3Jbr
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (9 available)
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fails to form, on six sides out of eight, in four embryos (J:157532)
• fails to form, on six sides out of eight, in four embryos (J:157532)
• missing, on five sides out of six, in three embryos (J:157532)
• missing, on five sides out of six, in three embryos (J:157532)




Genotype
MGI:4418306
cn3
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (9 available)
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 1 week after birth, few mice are still alive (J:155885)
• 1 week after birth, few mice are still alive (J:155885)

nervous system
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice (J:155885)
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice (J:155885)
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice (J:155885)
• rhythmic phrenic discharges are less frequent than in wild-type mice (J:155885)
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice (J:155885)
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice (J:155885)
• rhythmic phrenic discharges are less frequent than in wild-type mice (J:155885)
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice (J:155885)

growth/size/body
• surviving mice are smaller than wild-type mice (J:155885)
• surviving mice are smaller than wild-type mice (J:155885)

cellular
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice (J:155885)
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice (J:155885)
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)




Genotype
MGI:4418303
cn4
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pgk1-cre)1Lni/0
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at E13.5 (J:155885)
• mice die at E13.5 (J:155885)




Genotype
MGI:4418304
cn5
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pou3f4-cre)32Cren/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit phenotypic defects observed in Phox2btm1Jbr homozygotes (J:155885)
• mice exhibit phenotypic defects observed in Phox2btm1Jbr homozygotes (J:155885)




Genotype
MGI:4418307
cn6
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Egr2tm2(cre)Pch/Egr2+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2tm2(cre)Pch mutation (1 available); any Egr2 mutation (3 available)
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 1 week after birth, mice are dead (J:155885)
• 1 week after birth, mice are dead (J:155885)

nervous system
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice (J:155885)
• rhythmic phrenic discharges are less frequent than in wild-type mice (J:155885)
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice (J:155885)
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice (J:155885)
• rhythmic phrenic discharges are less frequent than in wild-type mice (J:155885)
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice (J:155885)

cellular
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice (J:155885)




Genotype
MGI:4438210
cn7
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• absence of all head parasympathetic ganglia (J:157532)
• absence of all head parasympathetic ganglia (J:157532)




Genotype
MGI:4438213
cn8
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Tg(Pou3f4-cre)32Cren/0
Genetic
Background
involves: 129S2/SvPas * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (8 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite the absence of visceral or branchial motoneurons, the main trunk of the facial nerve is present (J:157532)
• despite the absence of visceral or branchial motoneurons, the main trunk of the facial nerve is present (J:157532)
• visceromotor neurons are not produced (J:157532)
• absence of visceral or branchial motoneurons (J:157532)
• visceromotor neurons are not produced (J:157532)
• absence of visceral or branchial motoneurons (J:157532)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory