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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sdhdtm1Jpb
targeted mutation 1, Jean-Pierre Bayley
MGI:4418212
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sdhdtm1Jpb/Sdhdtm1Jpb 129P2/OlaHsd-Sdhdtm1Jpb MGI:4418215
ht2
Sdhdtm1Jpb/Sdhd+ either: 129P2/OlaHsd-Sdhdtm1Jpb or (involves: 129P2/OlaHsd * C57BL/6J) MGI:4418214
cx3
H19tm1Tilg/H19+
Sdhdtm1Jpb/Sdhd+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:4418216


Genotype
MGI:4418215
hm1
Allelic
Composition
Sdhdtm1Jpb/Sdhdtm1Jpb
Genetic
Background
129P2/OlaHsd-Sdhdtm1Jpb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhdtm1Jpb mutation (0 available); any Sdhd mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4418214
ht2
Allelic
Composition
Sdhdtm1Jpb/Sdhd+
Genetic
Background
either: 129P2/OlaHsd-Sdhdtm1Jpb or (involves: 129P2/OlaHsd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhdtm1Jpb mutation (0 available); any Sdhd mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile with no indications of paraganglioma or pheochromocytoma and no abnormalities detected in the carotid body or adrenal medulla at any age in contrast to expectations from human disease data

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Paragangliomas 1; PGL1 168000 J:155380




Genotype
MGI:4418216
cx3
Allelic
Composition
H19tm1Tilg/H19+
Sdhdtm1Jpb/Sdhd+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Tilg mutation (0 available); any H19 mutation (4 available)
Sdhdtm1Jpb mutation (0 available); any Sdhd mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• no paragangliomas nor pheochromocytomas are detected in mice at up to 29 months of age in contrast to expectations from human disease data

nervous system
N
• no significant changes in carotid body or the adrenal medulla are seen





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory