Mouse Genome Informatics
hm1
    Sdhdtm1Jpb/Sdhdtm1Jpb
129P2/OlaHsd-Sdhdtm1Jpb
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• die before E10.5


Mouse Genome Informatics
ht2
    Sdhdtm1Jpb/Sdhd+
either: 129P2/OlaHsd-Sdhdtm1Jpb or (involves: 129P2/OlaHsd * C57BL/6J)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• viable and fertile with no indications of paraganglioma or pheochromocytoma and no abnormalities detected in the carotid body or adrenal medulla at any age in contrast to expectations from human disease data

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Paragangliomas 1; PGL1 168000 J:155380


Mouse Genome Informatics
cx3
    H19tm1Tilg/H19+
Sdhdtm1Jpb/Sdhd+

involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
N
• no paragangliomas nor pheochromocytomas are detected in mice at up to 29 months of age in contrast to expectations from human disease data (J:155380)

nervous system
N
• no significant changes in carotid body or the adrenal medulla are seen (J:155380)