Phenotypes associated with this allele

• Allele Symbol: Aqp12^tm1Rai
• Allele Name: targeted mutation 1, Tatemitsu Rai
• Allele ID: MGI:4418194
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aqp12^tm1Rai/Aqp12^tm1Rai	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4418195

Genotype
MGI:4418195

hm1

• Allelic Composition: Aqp12^tm1Rai/Aqp12^tm1Rai
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased cholesterol level ( J:155920 )

• increased total cholesterol levels

endocrine/exocrine glands

abnormal pancreatic acinar cell zymogen granule morphology ( J:155920 )

• high doses of cholecystokinin-8 lead to fusion of zymogen granules to form large vacuoles

increased susceptibility to induced pancreatitis ( J:155920 )

• induced by caerulein

• significantly elevated serum amylase and lipase

• significant edema and inflammation

• necrotic acinar cells develop

digestive/alimentary system

abnormal pancreatic acinar cell zymogen granule morphology ( J:155920 )

• high doses of cholecystokinin-8 lead to fusion of zymogen granules to form large vacuoles

immune system

increased susceptibility to induced pancreatitis ( J:155920 )

• induced by caerulein

• significantly elevated serum amylase and lipase

• significant edema and inflammation

• necrotic acinar cells develop