Phenotypes associated with this allele

• Allele Symbol: Mir206^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:4418173
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir206^tm1Eno/Mir206^tm1Eno	involves: 129S/SvEv * C57BL/6	MGI:4418182
cx2	Mir206^tm1Eno/Mir206^tm1Eno Tg(SOD1*G93A)^dl1Gur/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:4418180

Genotype
MGI:4418182

hm1

• Allelic Composition: Mir206^tm1Eno/Mir206^tm1Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal motor nerve collateral sprouting ( J:155806 )

• after injury (cutting or crushing), reinnervation of denervated muscles by motor axons is delayed

• however, in the absence of injury no defects in neuromuscular junctions are detected

• after injury motor axons often sprout beyond the NMJs after injury motor axons often sprout beyond the NMJs after injury motor axons often sprout beyond the NMJs after injury motor axons often sprout beyond the NMJs

Genotype
MGI:4418180

cx2

• Allelic Composition: Mir206^tm1Eno/Mir206^tm1Eno; Tg(SOD1*G93A)^dl1Gur/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

mortality/aging

premature death ( J:155806 )

• average death at 244 days compared to 266 days in mice carrying the transgene alone

skeleton

kyphosis ( J:155806 )

muscle

skeletal muscle atrophy ( J:155806 )

• at 7.5 months of age

behavior/neurological

hindlimb paralysis ( J:155806 )

• accelerated compared to transgene alone

nervous system

abnormal neuromuscular synapse morphology ( J:155806 )

• neuromuscular junctions are disorganized and show imperfect colocalization of nerve and postsynaptic sites