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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf11atm1.2Pngr
targeted mutation 1.2, Josef M Penninger
MGI:4415802
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf11atm1.2Pngr/Tnfrsf11atm1.2Pngr B6.Cg-Tnfrsf11atm1.2Pngr MGI:4415815
cn2
 		Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Gfap-cre)2Brn/0		 involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N MGI:4415817
cn3
 		Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Nes-cre)1Kln/0		 involves: 129 * C57BL/6 * C57BL/6NTac * SJL MGI:4415816


Genotype
MGI:4415815
hm1
Allelic
Composition		 Tnfrsf11atm1.2Pngr/Tnfrsf11atm1.2Pngr
Genetic
Background		 B6.Cg-Tnfrsf11atm1.2Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf11atm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased osteoclast cell number ( J:155398 )
• mice lack TRAP (Acp5)+ osteoclasts
osteopetrosis ( J:155398 )
• severe

immune system
decreased osteoclast cell number ( J:155398 )
• mice lack TRAP (Acp5)+ osteoclasts

craniofacial

hematopoietic system
decreased osteoclast cell number ( J:155398 )
• mice lack TRAP (Acp5)+ osteoclasts

growth/size/body
failure of tooth eruption ( J:155398 )




Genotype
MGI:4415817
cn2
Allelic
Composition		 Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Gfap-cre)2Brn/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-cre)2Brn mutation (1 available)
Tnfrsf11atm1.1Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
Tnfrsf11atm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal body temperature homeostasis ( J:155398 )
• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice
abnormal circadian temperature homeostasis ( J:155398 )
• in female mice during the light phase
impaired febrile response ( J:155398 )
• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice
decreased prostaglandin level ( J:155398 )
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice
abnormal response/metabolism to endogenous compounds ( J:155398 )
• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice
• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

immune system
decreased susceptibility to endotoxin shock ( J:155398 )
• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice




Genotype
MGI:4415816
cn3
Allelic
Composition		 Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Tnfrsf11atm1.1Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
Tnfrsf11atm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal body temperature homeostasis ( J:155398 )
• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice
abnormal circadian temperature homeostasis ( J:155398 )
• in female mice during the light phase
impaired febrile response ( J:155398 )
• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice
decreased prostaglandin level ( J:155398 )
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice
abnormal response/metabolism to endogenous compounds ( J:155398 )
• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice
• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

immune system
decreased susceptibility to endotoxin shock ( J:155398 )
• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice




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Send questions and comments to User Support. 		last database update
02/16/2021
MGI 6.16 		The Jackson Laboratory