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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfrsf11atm1.2Pngr
targeted mutation 1.2, Josef M Penninger
MGI:4415802
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfrsf11atm1.2Pngr/Tnfrsf11atm1.2Pngr B6.Cg-Tnfrsf11atm1.2Pngr MGI:4415815
cn2
Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Gfap-cre)2Brn/0
involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N MGI:4415817
cn3
Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * C57BL/6NTac * SJL MGI:4415816


Genotype
MGI:4415815
hm1
Allelic
Composition
Tnfrsf11atm1.2Pngr/Tnfrsf11atm1.2Pngr
Genetic
Background
B6.Cg-Tnfrsf11atm1.2Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf11atm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• mice lack TRAP (Acp5)+ osteoclasts
• severe

immune system
• mice lack TRAP (Acp5)+ osteoclasts

craniofacial

hematopoietic system
• mice lack TRAP (Acp5)+ osteoclasts

growth/size/body




Genotype
MGI:4415817
cn2
Allelic
Composition
Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Gfap-cre)2Brn/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-cre)2Brn mutation (1 available)
Tnfrsf11atm1.1Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
Tnfrsf11atm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice
• in female mice during the light phase
• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice
• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

immune system
• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice




Genotype
MGI:4415816
cn3
Allelic
Composition
Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Tnfrsf11atm1.1Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
Tnfrsf11atm1.2Pngr mutation (0 available); any Tnfrsf11a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice
• in female mice during the light phase
• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice
• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

immune system
• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice





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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory