• following treatment with tamoxifen, cultured tracheal ciliated epithelium exhibits no ciliary activity likely due to a lack of outer dynein arms unlike similarly treated wild-type samples

• however, epithelium morphology and number of ciliated cells are normal following treatment with tamoxifen

• tamoxifen-treated mice exhibit chronic rhinosinusitis unlike wild-type mice

• however, no lung inflammation develops in tamoxifen-treated mice

• after 3 months, tamoxifen-treated mice exhibit absent mucociliary clearance in the nasopharynx and a 50% decreased in the trachea compared with wild-type mice

• after 6 months, 3 of 4 tamoxifen-treated mice exhibit no mucociliary clearance in the trachea while 1 of 4 mice exhibit a substantial reduction in clearance compared with similarly treated wild-type mice

• after 7.5 months, tamoxifen-treated mice exhibit no mucociliary clearance in the trachea compared with similarly treated wild-type mice

• tamoxifen-treated mice exhibit chronic rhinosinusitis unlike wild-type mice

• however, no lung inflammation develops in tamoxifen-treated mice

• despite ciliary defects, tamoxifen-treated mice exhibit no evidence hydroencephaly (J:155730)