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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cavin2tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:4415387
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg involves: C57BL/6 * C57BL/6NTac MGI:5549944
cx2
 		Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg 		involves: C57BL/6 * C57BL/6NTac MGI:5549946


Genotype
MGI:5549944
hm1
Allelic
Composition		 Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Cell Lines 11065A-H7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin2tm1(KOMP)Vlcg mutation (0 available); any Cavin2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular endothelial cell morphology ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination
• adipose endothelium contains fewer caveolae than in wild-type mice
• however, calveolae in the heart and muscle are normal
abnormal lung vasculature morphology ( J:205741 )
• gaps in the lung capillary
abnormal pulmonary endothelial cell surface ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination

cellular
abnormal plasma membrane morphology ( J:205741 )
• lung endothelia contain very few caveolae
• adipose endothelium and adipocytes contains fewer caveolae than in wild-type mice
• however, calveolae in the heart and muscle are normal

adipose tissue
abnormal fat cell morphology ( J:205741 )
• adipocytes contains fewer caveolae than in wild-type mice

respiratory system
abnormal lung vasculature morphology ( J:205741 )
• gaps in the lung capillary
abnormal pulmonary endothelial cell surface ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination




Genotype
MGI:5549946
cx2
Allelic
Composition		 Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Cell Lines 11448A-D8, 11065A-H7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin2tm1(KOMP)Vlcg mutation (0 available); any Cavin2 mutation (21 available)
Cavin3tm1(KOMP)Vlcg mutation (1 available); any Cavin3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular endothelial cell morphology ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination
• however, calveolae in the heart is normal
abnormal pulmonary endothelial cell surface ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination

cellular
abnormal plasma membrane morphology ( J:205741 )
• lung endothelia contain very few caveolae
• however, calveolae in the heart is normal

respiratory system
abnormal pulmonary endothelial cell surface ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory