Phenotypes associated with this allele

• Allele Symbol: Nefm^tm1Dwc
• Allele Name: targeted mutation 1, Don W Cleveland
• Allele ID: MGI:4415254
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nefm^tm1Dwc/Nefm^tm1Dwc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4415255

Genotype
MGI:4415255

hm1

• Allelic Composition: Nefm^tm1Dwc/Nefm^tm1Dwc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:155659 )

N • mice exhibit normal myelin-dependent radial axonal growth and motor nerve conduction velocity

abnormal axon morphology ( J:155659 )

• at 2 months, mice exhibit a small difference in the distribution of axonal diameters compared to wild-type mice

• however, by 6 months the distribution of axonal diameters is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:155659 )

N • mice exhibit normal recovery after nerve injury

behavior/neurological

behavior/neurological phenotype ( J:155659 )

N • mice exhibit normal locomotor activity