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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(S100A8-cre,-EGFP)1Ilw
transgene insertion 1, Irving L Weissman
MGI:4415239
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Syktm1Tyb/Syktm1.2Tara
Tg(S100A8-cre,-EGFP)1Ilw/0
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6 MGI:4415251
cn2
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce/Gt(ROSA)26Sor+
Tg(S100A8-cre,-EGFP)1Ilw/0
involves: C3H * C57BL/6 * C57BL/6J MGI:6196860


Genotype
MGI:4415251
cn1
Allelic
Composition
Syktm1Tyb/Syktm1.2Tara
Tg(S100A8-cre,-EGFP)1Ilw/0
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.2Tara mutation (1 available); any Syk mutation (31 available)
Syktm1Tyb mutation (0 available); any Syk mutation (31 available)
Tg(S100A8-cre,-EGFP)1Ilw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system
• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice




Genotype
MGI:6196860
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce/Gt(ROSA)26Sor+
Tg(S100A8-cre,-EGFP)1Ilw/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce mutation (0 available); any Gt(ROSA)26Sor mutation (765 available)
Tg(S100A8-cre,-EGFP)1Ilw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice are runted
• mice treated with an alpha IL-1R blocking antibody show weight gain

hematopoietic system
• increase in neutrophils in the spleen and lymph nodes
• increase in monocytes in the spleen and lymph nodes

homeostasis/metabolism
• mice exhibit increased cytokine levels, with IL-18 having the greatest increase
• mice develop joint swelling
• mice treated with an alpha IL-1R blocking antibody show deceased joint swelling

immune system
• increase in neutrophils in the spleen and lymph nodes
• increase in monocytes in the spleen and lymph nodes
• mice exhibit increased cytokine levels, with IL-18 having the greatest increase

skeleton
• mice develop joint swelling
• mice treated with an alpha IL-1R blocking antibody show deceased joint swelling





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory