All Phenotypes Syne1<tm1Chen> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1Chen/Syne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss	MGI:5703835
cn2	Syne1^tm1Chen/Syne1^tm1Chen Tg(Nkx2-5-cre)9Eno/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss	MGI:5703836
cx3	Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1Chen/Syne2^tm1.1Chen	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss	MGI:5703837

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ultrastructural nuclear abnormalities in Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

cardiovascular system

cardiovascular system phenotype ( J:211007 )

N	• heart rate remains unchanged through course of study

abnormal heart morphology ( J:211007 )

abnormal heart weight ( J:211007 )

• significant increase in heart weight/body weight and heart weight/total length ratios at 10 weeks of age

thin ventricular wall ( J:211007 )

• wall thinning observed at 10 weeks but not at 5 weeks of age

• thinning continues through 25 and 52 weeks

cardiac fibrosis ( J:211007 )

• at 10 weeks

abnormal cardiovascular system physiology ( J:211007 )

decreased cardiac muscle contractility ( J:211007 )

• diminished fractional shortening at 10 weeks but not 5 weeks of age

• fractional shortening continues to decline at 25 and 52 weeks

increased cardiomyocyte apoptosis ( J:211007 )

• at 10 weeks of age

cellular

increased cardiomyocyte apoptosis ( J:211007 )

• at 10 weeks of age

abnormal cell nucleus morphology ( J:211007 )

• nuclei are considerably enlarged and binuclei are closer together

• nuclei are less circular

• nuclear abnormalities begin to appear at 1 day of age

muscle

decreased cardiac muscle contractility ( J:211007 )

• diminished fractional shortening at 10 weeks but not 5 weeks of age

• fractional shortening continues to decline at 25 and 52 weeks

increased cardiomyocyte apoptosis ( J:211007 )

• at 10 weeks of age

Allelic Composition	Syne1^tm1Chen/Syne1^tm1Chen Tg(Nkx2-5-cre)9Eno/?
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne1^tm1Chen mutation (0 available); any Syne1 mutation (202 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:211007 )

• nuclei are enlarged

• nuclei are less circular

• nuclei are closer together in binuclear cardiomyocytes

Allelic Composition	Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1Chen/Syne2^tm1.1Chen
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne1^tm1Chen mutation (0 available); any Syne1 mutation (202 available)
Syne2^tm1.1Chen mutation (0 available); any Syne2 mutation (297 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:211007 )

• nuclei are enlarged

• nuclei are less circular

• nuclei are closer together in binuclear cardiomyocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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