Mouse Genome Informatics
hm1
    Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• no elevated reactive astrocytosis, neurodegeneration or somatic accumulation of alpha-synuclein is observed in brains of 20-month old mice compared to controls; no aggregates of alpha-synuclein form in mutant brains (J:156512)
• a moderate increase in microglial activation is observed in the brains of 20-month old animals

immune system
• a moderate increase in microglial activation is observed in the brains of 20-month old animals

hematopoietic system
• a moderate increase in microglial activation is observed in the brains of 20-month old animals


Mouse Genome Informatics
hm2
    Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
involves: 129X1/SvJ * C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• neurite length is increased compared to in wild-type mice
• total neurite outgrowth is increased compare to in wild-type mice
• however, the number of primary neurites is normal
• longer than in wild-type mice


Mouse Genome Informatics
cx3
    Lrrk2tm1.1Cai/Lrrk2+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA*A53T)E2Cai/0

involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• somatic alpha synuclein in neurons is apparent at 12 months
• increased microglial activation is observed in the brain at 12 months
• numbers of residual neurons is significantly lower than non transgenic controls
• significant at 12 months
• the Golgi complex shows severe fragmentation in 12 month old animals
• neurodegeneration significant at 12 months

immune system
• increased microglial activation is observed in the brain at 12 months

hematopoietic system
• increased microglial activation is observed in the brain at 12 months


Mouse Genome Informatics
cx4
    Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA*A53T)E2Cai/0

involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• no apparent neurodegeneration is observed in 12-month old mice; no significant elevation of astrocytosis, microgliosis or somatic accumulation of alpha-synuclein is detected in striatum at 12 months (J:156512)