Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation
(1 available);
any
Lrrk2 mutation
(90 available)
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nervous system
N |
• no elevated reactive astrocytosis, neurodegeneration or somatic accumulation of alpha-synuclein is observed in brains of 20-month old mice compared to controls; no aggregates of alpha-synuclein form in mutant brains
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• a moderate increase in microglial activation is observed in the brains of 20-month old animals
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immune system
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• a moderate increase in microglial activation is observed in the brains of 20-month old animals
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hematopoietic system
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• a moderate increase in microglial activation is observed in the brains of 20-month old animals
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation
(1 available);
any
Lrrk2 mutation
(90 available)
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nervous system
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• neurite length is increased compared to in wild-type mice
• total neurite outgrowth is increased compare to in wild-type mice
• however, the number of primary neurites is normal
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• longer than in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation
(1 available);
any
Lrrk2 mutation
(90 available)
Tg(Camk2a-tTA)1Mmay mutation
(8 available)
Tg(tetO-SNCA*A53T)E2Cai mutation
(1 available)
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nervous system
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• somatic alpha synuclein in neurons is apparent at 12 months
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• increased microglial activation is observed in the brain at 12 months
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• numbers of residual neurons is significantly lower than non transgenic controls
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• significant at 12 months
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• the Golgi complex shows severe fragmentation in 12 month old animals
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• neurodegeneration significant at 12 months
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immune system
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• increased microglial activation is observed in the brain at 12 months
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hematopoietic system
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• increased microglial activation is observed in the brain at 12 months
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation
(1 available);
any
Lrrk2 mutation
(90 available)
Tg(Camk2a-tTA)1Mmay mutation
(8 available)
Tg(tetO-SNCA*A53T)E2Cai mutation
(1 available)
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nervous system
N |
• no apparent neurodegeneration is observed in 12-month old mice; no significant elevation of astrocytosis, microgliosis or somatic accumulation of alpha-synuclein is detected in striatum at 12 months
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