Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn7tm3.1Tjj mutation
(0 available);
any
Clcn7 mutation
(40 available)
Tg(APOE-cre)VITew mutation
(0 available)
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cellular
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• degradation of the endocytosed protein in proximal tubule cells of the kidneys is disrupted compared to in wild-type mice
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renal/urinary system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn5tm1Tjj mutation
(0 available);
any
Clcn5 mutation
(16 available)
Clcn7tm3.1Tjj mutation
(0 available);
any
Clcn7 mutation
(40 available)
Tg(APOE-cre)VITew mutation
(0 available)
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cellular
renal/urinary system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn7tm3.1Tjj mutation
(0 available);
any
Clcn7 mutation
(40 available)
Emx1tm1.1(cre)Ito mutation
(1 available);
any
Emx1 mutation
(34 available)
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mortality/aging
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N |
• unlike Clcn7tm2Tjj homozygotes, mice have a normal lifespan
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nervous system
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• at 20 weeks in the cerebral cortex
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• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
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• at 20 weeks, the dentate gyrus exhibits conspicuous degeneration unlike in wild-type mice
• hippocampal structures are no longer detected by 1.5 years of age
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• mice exhibit severe neuronal cell loss as early as 30 days after birth
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• the cerebral cortex is reduced at 4 to 5 months of age
• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
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• nearly all cortical neurons are lost by 1 year of age
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• at 20 weeks in the cerebral cortex
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• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
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• progressive with severe neuronal cell loss as early as 30 days after birth
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behavior/neurological
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• at 4 to 5 months of age
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cellular
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• mice exhibit a lysosomal storage phenotype in the forebrain with altered Lamp-1 distribution compared to in wild-type mice
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skeleton
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N |
• unlike Clcn7tm2Tjj homozygotes, mice exhibit normal bone density
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growth/size/body
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N |
• unlike Clcn7tm2Tjj homozygotes, mice exhibit normal growth
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immune system
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• at 20 weeks in the cerebral cortex
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hematopoietic system
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• at 20 weeks in the cerebral cortex
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Analysis Tools