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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pla2g10tm1Kiku
targeted mutation 1, Kiyotaka Kugiyama
MGI:4412409
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pla2g10tm1Kiku/Pla2g10tm1Kiku B6.129P2-Pla2g10tm1Kiku MGI:4412410
hm2
Pla2g10tm1Kiku/Pla2g10tm1Kiku involves: 129P2/OlaHsd MGI:4461177


Genotype
MGI:4412410
hm1
Allelic
Composition
Pla2g10tm1Kiku/Pla2g10tm1Kiku
Genetic
Background
B6.129P2-Pla2g10tm1Kiku
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g10tm1Kiku mutation (0 available); any Pla2g10 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening compared with similarly treated wild-type mice
• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening, less of an increase in left ventricle end-systolic dimensions, and reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
• following myocardial ischemia and reperfusion injury, mice exhibit decreased infarction size compared with similarly treated wild-type mice
• following myocardial ischemia and reperfusion injury, lethally irradiated wild-type mice reconstituted with bone marrow exhibit smaller infarction size compared with mice reconstituted with wild-type bone marrow

immune system
N
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal edema
• following myocardial ischemia and reperfusion injury, mice exhibit reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
• C5a-, fMLP-, or A23187-stimulated neutrophils exhibit lower respiratory-burst compared with similarly treated wild-type cells
• neutrophils release less elastase in response to serum-opsonized zymosan compared with similarly treated wild-type cells
• neutrophil extracellular release of arachidonic acid in response to C5a of fMLP is lower than similarly treated wild-type cells
• however, neutrophil physiology in response to arachidonic acid and PMA is normal
• in C5a-, fMLP-, or A23187-stimulated neutrophils

homeostasis/metabolism
• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening, less of an increase in left ventricle end-systolic dimensions, and reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
• following myocardial ischemia and reperfusion injury, mice exhibit decreased infarction size compared with similarly treated wild-type mice
• following myocardial ischemia and reperfusion injury, lethally irradiated wild-type mice reconstituted with bone marrow exhibit smaller infarction size compared with mice reconstituted with wild-type bone marrow

muscle
• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening compared with similarly treated wild-type mice

hematopoietic system
• following myocardial ischemia and reperfusion injury, mice exhibit reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
• C5a-, fMLP-, or A23187-stimulated neutrophils exhibit lower respiratory-burst compared with similarly treated wild-type cells
• neutrophils release less elastase in response to serum-opsonized zymosan compared with similarly treated wild-type cells
• neutrophil extracellular release of arachidonic acid in response to C5a of fMLP is lower than similarly treated wild-type cells
• however, neutrophil physiology in response to arachidonic acid and PMA is normal
• in C5a-, fMLP-, or A23187-stimulated neutrophils

cellular
• in C5a-, fMLP-, or A23187-stimulated neutrophils




Genotype
MGI:4461177
hm2
Allelic
Composition
Pla2g10tm1Kiku/Pla2g10tm1Kiku
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g10tm1Kiku mutation (0 available); any Pla2g10 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• reduced phospholipase A2 (PLA2) enzymatic activity in cauda epididymal fluid





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory