• at 4 months, mice exhibit tau plaques unlike wild-type mice

• tau deposits worsen with age

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice

• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice

• in a novel arena at 2 and 12 months but not at 4 months

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

• induced by tetanic stimulation independent of age and amyloid plaque deposition

• induced by tetanic stimulation

• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice

• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice

• on at rotarod at 4 months

• at 4 to 12 months

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal