Mouse Genome Informatics
cx1
    Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0

B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age

behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
• in a novel arena at 2 and 12 months but not at 4 months

other phenotype
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age


Mouse Genome Informatics
tg2
    Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
C57BL/6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice
• however, proliferation of neuronal progenitors is normal
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
• induced by tetanic stimulation independent of age and amyloid plaque deposition
• induced by tetanic stimulation

behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
• on at rotarod at 4 months

growth/size
• at 4 to 12 months

other phenotype
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age

cellular
• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice
• however, proliferation of neuronal progenitors is normal

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:165986