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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zfp24hmcns
hypomyelinated central nervous system
MGI:4412036
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zfp24hmcns/Zfp24hmcns C3.Cg-a Zfp24hmcns/GrsrJ MGI:4429672
ht2
Zfp24hmcns/Zfp24tm1.2Pop involves: 129S4/SvJae * C3H/HeJ * C57BL/6 MGI:4429674


Genotype
MGI:4429672
hm1
Allelic
Composition
Zfp24hmcns/Zfp24hmcns
Genetic
Background
C3.Cg-a Zfp24hmcns/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp24hmcns mutation (1 available); any Zfp24 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die by P25

behavior/neurological
• at P14
• at P14

nervous system
• at P14
• reduced number of post-mitotic and myelinating oligodendrocytes in the brainstem
• myelin deficiency in the central nervous system, however axons in the peripheral nervous system are normally myelinated
• rare myelin sheaths in central nervous system are thinner
• apparent lack of white matter at P14




Genotype
MGI:4429674
ht2
Allelic
Composition
Zfp24hmcns/Zfp24tm1.2Pop
Genetic
Background
involves: 129S4/SvJae * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp24hmcns mutation (1 available); any Zfp24 mutation (21 available)
Zfp24tm1.2Pop mutation (0 available); any Zfp24 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

nervous system
• severe hypomyelination in the CNS





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory