All Phenotypes Ercc3<tm1.1Gima> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ercc3^tm1.1Gima
targeted mutation 1.1, Giuseppina Giglia-Mari
MGI:4410296

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ercc3^tm1.1Gima/Ercc3^tm1.1Gima	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)	MGI:4410311
cx2	Ercc3^tm1.1Gima/Ercc3^tm1.1Gima Xpc^tm1Ecf/Xpc^tm1Ecf	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * FVB/N)	MGI:4410312

Allelic Composition	Ercc3^tm1.1Gima/Ercc3^tm1.1Gima
Genetic Background	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc3^tm1.1Gima mutation (0 available); any Ercc3 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:154596 )

N	• mice exhibit normal aging

cellular

cellular phenotype ( J:154596 )

N	• dermal fibroblasts exhibit normal sensitivity to UV-irradiation

reproductive system

reproductive system phenotype ( J:154596 )

N	• mice are fertile

neoplasm

neoplasm ( J:154596 )

N	• mice exhibit normal carcinogenesis

Allelic Composition	Ercc3^tm1.1Gima/Ercc3^tm1.1Gima Xpc^tm1Ecf/Xpc^tm1Ecf
Genetic Background	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc3^tm1.1Gima mutation (0 available); any Ercc3 mutation (31 available)
Xpc^tm1Ecf mutation (1 available); any Xpc mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cellular sensitivity to ultraviolet irradiation ( J:154596 )

• UV-treated dermal fibroblasts exhibit reduced survival compared with similarly treated wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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