Analysis Tools
nervous system
| N |
• mice exhibit normal development of the piriform cortex
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Allele Symbol Allele Name Allele ID |
Lhx2tm1.1Ddmo targeted mutation 1.1, Dennis D M OLeary MGI:4399043 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal development of the piriform cortex
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the telencephalon exhibits abnormal patterning compared to in wild-type mice
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• at P7, the cortices are half the size of the cortices in wild-type mice
• the neocortex is small with abnormal lamination patterns compared to in wild-type mice
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• the ectopic piriform cortex is 400% larger than the normal piriform cortex
• between E15.5 and P0 the endogenous piriform cortex disappears
• however, the neocortex is normal at E13.5
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• olfactory bulb projections continue beyond the ectopic piriform cortex and project into layer 1 through much of the neo cortex unlike in wild-type mice
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• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• at P7, the piriform cortex is absent from its normal ventral position
• however, the piriform cortex is present at E13.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the telencephalon exhibits abnormal patterning compared to in wild-type mice
|
|
• at P7, the cortices are half the size of the cortices in wild-type mice
• the neocortex is small with abnormal lamination patterns compared to in wild-type mice
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• the ectopic piriform cortex is 400% larger than the normal piriform cortex
• between E15.5 and P0 the endogenous piriform cortex disappears
• however, the neocortex is normal at E13.5
|
|
• olfactory bulb projections continue beyond the ectopic piriform cortex and project into layer 1 through much of the neo cortex unlike in wild-type mice
|
|
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• at P7, the piriform cortex is absent from its normal ventral position
• however, the piriform cortex is present at E13.5
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at P7, the cortices are half the size of the cortices in wild-type mice
• however, the piriform cortex and lateral cortex are positioned normally
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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