Mouse Genome Informatics
hm1
    Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
involves: 129 * C57BL/6 * FVB/N
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable


Mouse Genome Informatics
cn2
    Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
involves: 129
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces more cerebrovascular dysplasia in mutants than in similarly injected Engtm2.1Hma homozygotes, however gene deletion efficiency is higher in this mutant and when gene deletion efficiency is the same in both mutants, then this mutant shows fewer dysplastic vessels per gene copy than the Eng mutant
• however, mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus

nervous system
• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces more cerebrovascular dysplasia in mutants than in similarly injected Engtm2.1Hma homozygotes, however gene deletion efficiency is higher in this mutant and when gene deletion efficiency is the same in both mutants, then this mutant shows fewer dysplastic vessels per gene copy than the Eng mutant
• however, mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus

Mouse Models of Human Disease
OMIM IDRef(s)
Arteriovenous Malformations of the Brain 108010 J:196810


Mouse Genome Informatics
cn3
    Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+

involves: 129 * 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• adult mice administered with tamoxifen die 9-21 days after a single injection
• tamoxifen treated females show a shorter survival span than males

growth/size/body
• tamoxifen treated mutants show signs of illness such as slow movements, weight loss, pale paws, and low pO2 levels from 8-10 days after tamoxifen injection

cardiovascular system
• pulmonary arteries and veins are dilated
• high vascular permeability
• uterus shows signs of arteriovenous malformations in tamoxifen treated mutants
• mutants bearing excisional wounds on the dorsal skin and ear and treated with tamoxifen form arteriovenous shunts in the blood vessels near the wounds
• arteriovenous malformations in the GI tract of tamoxifen treated mutants are located in the Peyer's patches of small intestine and appendix
• in tamoxifen treated mutants
• in tamoxifen treated mutants
• tamoxifen treated mutants show signs of hemorrhages in the lungs

digestive/alimentary system
• arteriovenous malformations in the GI tract of tamoxifen treated mutants are located in the Peyer's patches of small intestine and appendix
• tamoxifen treated mutants exhibit darkened feces indicative of the presence of blood

hematopoietic system
• in tamoxifen treated mutants
• tamoxifen treated mutants exhibit reduced hematocrit

respiratory system