Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Id1tm3Bene mutation
(0 available);
any
Id1 mutation
(8 available)
Id2tm1Xdz mutation
(0 available);
any
Id2 mutation
(19 available)
Id3tm1Zhu mutation
(1 available);
any
Id3 mutation
(16 available)
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cellular
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• following tamoxifen-treatment of cultured neural stem cells
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nervous system
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• following tamoxifen-treatment of cultured neural stem cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1tm3Bene mutation
(0 available);
any
Id1 mutation
(8 available)
Id2tm1Xdz mutation
(0 available);
any
Id2 mutation
(19 available)
Id3tm1Zhu mutation
(1 available);
any
Id3 mutation
(16 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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mortality/aging
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• nearly all mice die within the first 24 hours after birth
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nervous system
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• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells
• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells
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• of neural stem cells in vitro and in vivo as determined by marker expression
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• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells
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• hypocellular at E18.5 and P0
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• disrupted pseudo-stratified architecture at E18.5
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cellular
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• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells
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• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells
• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells
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• of neural stem cells in vitro and in vivo as determined by marker expression
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• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1tm3Bene mutation
(0 available);
any
Id1 mutation
(8 available)
Id2tm1Xdz mutation
(0 available);
any
Id2 mutation
(19 available)
Id3tm1Zhu mutation
(1 available);
any
Id3 mutation
(16 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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nervous system
N |
• neural stem cells exhibit normal self-renewal and proliferation
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