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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Id1tm3Bene
targeted mutation 3, Robert Benezra
MGI:4366910
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Id1tm3Bene/Id1+ involves: C57BL/6 MGI:4415076
cn2
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu
involves: 129S4/SvJaeSor * C57BL/6 MGI:5428955
cn3
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5428946
cn4
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2+
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5428947


Genotype
MGI:4415076
ht1
Allelic
Composition
Id1tm3Bene/Id1+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1tm3Bene mutation (0 available); any Id1 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• no analysis details are provided




Genotype
MGI:5428955
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (502 available)
Id1tm3Bene mutation (0 available); any Id1 mutation (2 available)
Id2tm1Xdz mutation (0 available); any Id2 mutation (6 available)
Id3tm1Zhu mutation (1 available); any Id3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• following tamoxifen-treatment of cultured neural stem cells

nervous system
• following tamoxifen-treatment of cultured neural stem cells




Genotype
MGI:5428946
cn3
Allelic
Composition
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1tm3Bene mutation (0 available); any Id1 mutation (2 available)
Id2tm1Xdz mutation (0 available); any Id2 mutation (6 available)
Id3tm1Zhu mutation (1 available); any Id3 mutation (11 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• nearly all mice die within the first 24 hours after birth

nervous system
• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells
• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells
• of neural stem cells in vitro and in vivo as determined by marker expression
• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells
• hypocellular at E18.5 and P0
• disrupted pseudo-stratified architecture at E18.5
• at E18.5 and P0

cellular
• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells
• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells
• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells
• of neural stem cells in vitro and in vivo as determined by marker expression
• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells




Genotype
MGI:5428947
cn4
Allelic
Composition
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2+
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1tm3Bene mutation (0 available); any Id1 mutation (2 available)
Id2tm1Xdz mutation (0 available); any Id2 mutation (6 available)
Id3tm1Zhu mutation (1 available); any Id3 mutation (11 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• neural stem cells exhibit normal self-renewal and proliferation





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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory