All Phenotypes Pten<tm1.1Mwst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pten^tm1.1Mwst
targeted mutation 1.1, Michael Weinstein
MGI:4366755

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(TPO-cre)1Shk/0	involves: 129 * FVB/NCr	MGI:5897778
cn2	Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(TPO-cre)1Shk/0	involves: 129S1/Sv * 129X1/SvJ * FVB/NCr	MGI:5897675
cn3	Prkar1a^tm1.2Lsk/Prkar1a⁺ Pten^tm1.1Mwst/Pten⁺ Tg(TPO-cre)1Shk/0	involves: 129S1/Sv * 129X1/SvJ * FVB/NCr	MGI:5897775
cn4	Ets2^tm1Rgo/Ets2^tm5.1Rgo Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle/0	involves: 129S2/SvPas * FVB/N	MGI:4366764
cn5	Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul/0 Tg(S100a4-cre)1Gle/0	involves: FVB/N	MGI:4366766
cn6	Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle/0	involves: FVB/N	MGI:4366765

Allelic Composition	Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(TPO-cre)1Shk/0
Genetic Background	involves: 129 * FVB/NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1.1Mwst mutation (0 available); any Pten mutation (81 available)
Tg(TPO-cre)1Shk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal thyroid follicular cell morphology ( J:225245 )

• mice exhibit benign follicular thyroid hyperplasia

Allelic Composition	Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(TPO-cre)1Shk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1a^tm1.2Lsk mutation (1 available); any Prkar1a mutation (19 available)
Pten^tm1.1Mwst mutation (0 available); any Pten mutation (81 available)
Tg(TPO-cre)1Shk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:225245 )

• median survival age of 6 months

growth/size/body

weight loss ( J:225245 )

• males exhibit lower body weight beginning at 1 month of age which becomes statistically significant at 5 months of age

endocrine/exocrine glands

enlarged thyroid gland ( J:225245 )

increased thyroid carcinoma incidence ( J:225245 )

• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion

• tumors show a molecular signature similar to human sporadic follicular thyroid cancer

increased activity of thyroid gland ( J:225245 )

• mice are hyperthyroid

adipose tissue

decreased subcutaneous adipose tissue amount ( J:225245 )

• reduction in subcutaneous adipose tissue

decreased abdominal adipose tissue amount ( J:225245 )

• reduction in visceral adipose tissue

homeostasis/metabolism

increased circulating thyroxine level ( J:225245 )

• free T4 levels are increased

integument

decreased subcutaneous adipose tissue amount ( J:225245 )

• reduction in subcutaneous adipose tissue

neoplasm

increased thyroid carcinoma incidence ( J:225245 )

• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion

• tumors show a molecular signature similar to human sporadic follicular thyroid cancer

increased metastatic potential ( J:225245 )

• metastatic follicular thyroid carcinoma is seen in the lungs of 27% of mice; metastases are well differentiated, maintain follicular structure with colloid, and stain for thyroglobulin

• tumors exhibit only mild increases in proliferation rate compared to those in single homozygous Prkar1a^tm1.2Lsk Tg(TPO-cre)1Shk/0 mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid gland follicular carcinoma		DOID:3962	OMIM:188470	J:241066

Allelic Composition	Prkar1a^tm1.2Lsk/Prkar1a⁺ Pten^tm1.1Mwst/Pten⁺ Tg(TPO-cre)1Shk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:225245 )

• mice exhibit reduced survival compared to single heterozygotes

neoplasm

neoplasm ( J:225245 )

N	• mice do not show increased incidence of thyroid cancer

Allelic Composition	Ets2^tm1Rgo/Ets2^tm5.1Rgo Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2^tm1Rgo mutation (1 available); any Ets2 mutation (37 available)
Ets2^tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Pten^tm1.1Mwst mutation (0 available); any Pten mutation (81 available)
Tg(S100a4-cre)1Gle mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:153747 )

• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle mice

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

abnormal tumor morphology ( J:153747 )

• mammary tumors induced by NT2.5 exhibit decreased numbers of macrophages and recruitment of new vasculature compared to in similarly treated Pten^tm1.1Mwst homozygotes

integument

decreased mammary gland tumor incidence ( J:153747 )

• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle mice

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:153747 )

• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle mice

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

Allelic Composition	Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul/0 Tg(S100a4-cre)1Gle/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1.1Mwst mutation (0 available); any Pten mutation (81 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(S100a4-cre)1Gle mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:153747 )

• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul cells

• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

increased mammary adenocarcinoma incidence ( J:153747 )

integument

increased mammary gland tumor incidence ( J:153747 )

• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul cells

• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

increased mammary adenocarcinoma incidence ( J:153747 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:153747 )

• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul cells

• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

increased mammary adenocarcinoma incidence ( J:153747 )

Allelic Composition	Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1.1Mwst mutation (0 available); any Pten mutation (81 available)
Tg(S100a4-cre)1Gle mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

integument

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

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