Phenotypes associated with this allele

• Allele Symbol: Tg(FOXJ1-EGFP)85Leo
• Allele Name: transgene insertion 85, Lawrence Ostrowski
• Allele ID: MGI:4365542
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxj1^tm1.1Ctk/Foxj1^tm1.2Ctk Tg(FOXJ1-EGFP)85Leo/0 Tg(Nes-cre)1Kln/0	involves: C3H * C57BL/6 * C57BL/6J * SJL	MGI:5285556
cx2	Foxj1^tm1Slb/Foxj1^tm1Slb Tg(FOXJ1-EGFP)85Leo/0	involves: 129X1/SvJ * C3H * C57BL/6J	MGI:4415712

Genotype
MGI:5285556

cn1

• Allelic Composition: Foxj1^tm1.1Ctk/Foxj1^tm1.2Ctk; Tg(FOXJ1-EGFP)85Leo/0; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:174694 )

• postnatal radial glial progenitors fail to organize into clusters unlike in wild-type mice

• neural stem cells fail to form ependymal niches unlike in wild-type mice

• however, RC2+ radial glial cells transition into neural stem cells

cellular

abnormal neuron differentiation ( J:174694 )

• postnatal radial glial progenitors fail to organize into clusters unlike in wild-type mice

• neural stem cells fail to form ependymal niches unlike in wild-type mice

• however, RC2+ radial glial cells transition into neural stem cells

Genotype
MGI:4415712

cx2

• Allelic Composition: Foxj1^tm1Slb/Foxj1^tm1Slb; Tg(FOXJ1-EGFP)85Leo/0
• Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6J

nervous system

abnormal brain development ( J:154976 )

• at P21, cells cross-transplanted into wild type mice fail to develop into S100b+ ependymal calls or Gfap+ astrocytes unlike similarly treated wild-type cells

astrocytosis ( J:154976 )

• in the transit amplifying progenitor domain and striatal tissue of the subventricular zone