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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prps2tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4362501
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Prps2tm1a(KOMP)Wtsi/Y
Tg(IghMyc)22Bri/0
involves: C57BL/6N * SJL MGI:5648425
ot2
Prps2tm1a(KOMP)Wtsi/Y involves: C57BL/6N MGI:5648423


Genotype
MGI:5648425
cx1
Allelic
Composition
Prps2tm1a(KOMP)Wtsi/Y
Tg(IghMyc)22Bri/0
Genetic
Background
involves: C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prps2tm1a(KOMP)Wtsi mutation (0 available); any Prps2 mutation (13 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 60% of mice live beyond 200 days at which point most mice carrying the transgene alone have died

neoplasm
• dramatic delay in tumor initiation compared to mice carrying the transgene alone

hematopoietic system
N
• overall rate of protein synthesis in B lymphocytes is reduced towards normal levels unlik in mice carrying Tg(IghMyc)22Bri alone
• B lymphocytes show increased glucose uptake and increased rate of glucose oxidation compared to mice carrying the transgene alone
• no alterations in mitochondrial mass or mitochondrial membrane potential are detected
• dramatic increase in B lymphocytes compared to mice carrying the transgene alone

immune system
• B lymphocytes show increased glucose uptake and increased rate of glucose oxidation compared to mice carrying the transgene alone
• no alterations in mitochondrial mass or mitochondrial membrane potential are detected
• dramatic increase in B lymphocytes compared to mice carrying the transgene alone

cellular
• dramatic increase in B lymphocytes compared to mice carrying the transgene alone




Genotype
MGI:5648423
ot2
Allelic
Composition
Prps2tm1a(KOMP)Wtsi/Y
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prps2tm1a(KOMP)Wtsi mutation (0 available); any Prps2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• minor decrease in rates of purine nucleotide biosynthesis

immune system
• minor decrease in rates of purine nucleotide biosynthesis





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory