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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Eno2-ATN1)3Tx
transgene insertion 3, Tian Xu
MGI:4360669
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Atn1tm1Rexu/Atn1tm1Rexu
Tg(Eno2-ATN1)3Tx/0
involves: C57BL/6 * SJL/J MGI:4360689
tg2
Tg(Eno2-ATN1)3Tx/Tg(Eno2-ATN1)3Tx B6.Cg-Tg(Eno2-ATN1)3Tx MGI:4360690
tg3
Tg(Eno2-ATN1)3Tx/0 B6.Cg-Tg(Eno2-ATN1)3Tx MGI:4360691


Genotype
MGI:4360689
cx1
Allelic
Composition
Atn1tm1Rexu/Atn1tm1Rexu
Tg(Eno2-ATN1)3Tx/0
Genetic
Background
involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atn1tm1Rexu mutation (0 available); any Atn1 mutation (20 available)
Tg(Eno2-ATN1)3Tx mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system




Genotype
MGI:4360690
tg2
Allelic
Composition
Tg(Eno2-ATN1)3Tx/Tg(Eno2-ATN1)3Tx
Genetic
Background
B6.Cg-Tg(Eno2-ATN1)3Tx
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced life span (J:112706)
• early-onset Sodium Butyrate (SB, a HDAC inhibitor) treatment (from 4 weeks old) extends their average life span (13.7%) (J:112706)
• late-onset (from 12 weeks old) SB treatment extends the average life span (21.5%) (J:112706)
• reduced life span (J:112706)
• early-onset Sodium Butyrate (SB, a HDAC inhibitor) treatment (from 4 weeks old) extends their average life span (13.7%) (J:112706)
• late-onset (from 12 weeks old) SB treatment extends the average life span (21.5%) (J:112706)

nervous system
• neurons in the dentate cerebellar nucleus display somal atrophy (J:112706)
• neurons in the dentate cerebellar nucleus display somal atrophy (J:112706)
• extensive nuclear accumulation of Atrophin-1 and widespread nuclear inclusions in several brain regions (striatum, cortex, thalamus, red nucleus, dentate cerebellar nucleus, and Purkinje cells) (J:112706)
• extensive nuclear accumulation of Atrophin-1 and widespread nuclear inclusions in several brain regions (striatum, cortex, thalamus, red nucleus, dentate cerebellar nucleus, and Purkinje cells) (J:112706)

behavior/neurological
• progressively lose the capability to coordinate and balance in the rotarod test and the hanging wire test (J:112706)
• early-onset Sodium Butyrate (SB, a HDAC inhibitor) treatment (from 4 weeks old) delays the onset of motor impairments (J:112706)
• progressively lose the capability to coordinate and balance in the rotarod test and the hanging wire test (J:112706)
• early-onset Sodium Butyrate (SB, a HDAC inhibitor) treatment (from 4 weeks old) delays the onset of motor impairments (J:112706)

Mouse Models of Human Disease
OMIM ID Ref(s)
Dentatorubral-Pallidoluysian Atrophy; DRPLA 125370 J:112706




Genotype
MGI:4360691
tg3
Allelic
Composition
Tg(Eno2-ATN1)3Tx/0
Genetic
Background
B6.Cg-Tg(Eno2-ATN1)3Tx
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no neurodegeneration (J:112706)
• much weaker nuclear accumulation and nearly no inclusions (J:112706)
• normal life span (>60 week) (J:112706)
• no neurodegeneration (J:112706)
• much weaker nuclear accumulation and nearly no inclusions (J:112706)
• normal life span (>60 week) (J:112706)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory