Analysis Tools
mortality/aging
|
• during postnatal assessment, no mice are found
|
|
Allele Symbol Allele Name Allele ID |
Apctm2Rfo targeted mutation 2, Riccardo Fodde MGI:4360657 |
||||||||||||||||||||||||||||
| Summary |
6 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• during postnatal assessment, no mice are found
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice
|
• mice die prior to 18 weeks
|
 |
• 29% of male mice develop gastrointestinal tumors
|
|
• in 94% of female mice and 50% of male mice
|
|
• in 11% of female mice and 29% of male mice
|
|
• in 94% of female mice and 50% of male mice
|
|
• in 11% of female mice and 29% of male mice
|
|
|
• 29% of male mice develop gastrointestinal tumors
|
|
• in 94% of female mice and 50% of male mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice
|
• mice die prior to 16 weeks
|
|
• in 100% of virgin females and 29% of males
• all tumors exhibit squamous metaplasia
• however, mice do not exhibit an increased susceptibility to intestinal tumors
|
|
• primary mammary adenocarcinomas metastasize to the lungs
|
|
• in 29% of male mice
• all tumors exhibit squamous metaplasia
|
|
• in 100% of virgin females and 29% of males
• all tumors exhibit squamous metaplasia
• however, mice do not exhibit an increased susceptibility to intestinal tumors
|
|
• primary mammary adenocarcinomas metastasize to the lungs
|
|
• in 100% of virgin females and 29% of males
• all tumors exhibit squamous metaplasia
• however, mice do not exhibit an increased susceptibility to intestinal tumors
|
|
• primary mammary adenocarcinomas metastasize to the lungs
|
|
• in 29% of male mice
• all tumors exhibit squamous metaplasia
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice
|
• mice die prior to 21 weeks
|
|
• lung micro- and macro-metastases
|
|
|
• mice develop epidermal cysts with increased multiplicity in male mice
• however, mice do not exhibit an increased susceptibility to intestinal tumors
• all tumors exhibit squamous metaplasia
|
|
• in 86% of virgin females and 31% of males
|
|
• primary mammary adenocarcinomas metastasize to the lungs
(J:151494)
• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer
(J:204440)
|
|
|
• 31% of male mice develop liver tumors
• however, female mice do not develop liver tumors
• all tumors exhibit squamous metaplasia
|
|
|
• mice develop desmoids with increased multiplicity in male mice
|
|
• in 86% of virgin females and 31% of males
|
|
• primary mammary adenocarcinomas metastasize to the lungs
(J:151494)
• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer
(J:204440)
|
|
|
• with increased mutliplicity in males
|
|
• in 86% of virgin females and 31% of males
|
|
• primary mammary adenocarcinomas metastasize to the lungs
(J:151494)
• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer
(J:204440)
|
|
|
• with increased mutliplicity in males
|
|
|
• 31% of male mice develop liver tumors
• however, female mice do not develop liver tumors
• all tumors exhibit squamous metaplasia
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:204440 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Phenotypic analysis of the compound in cis Apctm2Rfo/Apc+ Smad4E6sad/Smad4+ mouse model
|
• unlike in Apctm2Rfo heterozygotes, mice develop multiple gastro-intestinal tumors and adenomatous polyps
|
|
• similar to in Apctm2Rfo heterozygotes
|
|
• unlike in Apctm2Rfo heterozygotes, mice develop multiple gastro-intestinal tumors and adenomatous polyps
|
|
• similar to in Apctm2Rfo heterozygotes
|
|
• similar to in Apctm2Rfo heterozygotes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• anterior truncation
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||