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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tbpl2tm1.1Lzt
targeted mutation 1.1, Laszlo Tora
MGI:4360523
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tbpl2tm1.1Lzt/Tbpl2tm1.1Lzt involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:4360539


Genotype
MGI:4360539
hm1
Allelic
Composition
Tbpl2tm1.1Lzt/Tbpl2tm1.1Lzt
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbpl2tm1.1Lzt mutation (0 available); any Tbpl2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• cyct-containing structures are found in the follicles

cellular
• at 6 weeks, abnormal oocyte development becomes more pronounced
• oocytes exhibit disorganized chromatin unlike wild-type cells
• at 2 weeks, granulosa cells fail to undergo apoptosis as in wild-type mice

reproductive system
• at 6 weeks, abnormal oocyte development becomes more pronounced
• oocytes exhibit disorganized chromatin unlike wild-type cells
• at 2 weeks, granulosa cells fail to undergo apoptosis as in wild-type mice
• at 6 weeks, follicles are gradually depleted unlike in wild-type mice
• ovaries lack mature ovarian follicles unlike in wild-type mice
• ovaries contain fewer secondary follicles, including fewer preantral and antral follicles, compared to in wild-type mice
• before or during secondary follicle formation
• ovaries contain fewer primary follicles compared to in wild-type mice
• mice exhibit an increase in the number of immature follicles compared to in wild-type mice
• cyct-containing structures are found in the follicles
• at 6 weeks
• mice fail to ovulate when treated with hormones unlike similarly treated wild-type mice

endocrine/exocrine glands
• at 6 weeks, follicles are gradually depleted unlike in wild-type mice
• ovaries lack mature ovarian follicles unlike in wild-type mice
• ovaries contain fewer secondary follicles, including fewer preantral and antral follicles, compared to in wild-type mice
• before or during secondary follicle formation
• ovaries contain fewer primary follicles compared to in wild-type mice
• mice exhibit an increase in the number of immature follicles compared to in wild-type mice
• cyct-containing structures are found in the follicles
• at 6 weeks





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory