Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp-RTN3)2Yanr
• Allele Name: transgene insertion 2, Riqiang Yan
• Allele ID: MGI:4359884
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Prnp-RTN3)2Yanr/0	involves: C57BL/6 * FVB/N	MGI:4359924

Genotype
MGI:4359924

tg1

• Allelic Composition: Tg(Prnp-RTN3)2Yanr/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial reference memory ( J:122560 )

• transgenic mice perform much more poorly than wild-type mice on a Barnes circular maze for 7 days following a 2 day training period; unlike controls, some mice cannot find the escape box within the 300s time period

nervous system

abnormal hippocampus morphology ( J:122560 )

• RTN3 immunoreactive dystrophic neurites (RIDNs) spread throughout the entire hippocampal regions at 9 months, and are most dense in the CA1 region

abnormal hippocampus CA1 region morphology ( J:122560 )

• dispersed globular-, bulb-, or ring-shaped RTN3 immunoreactive dystrophic neurites (RIDNs) develop throughout the CA1 region by 4 months of age

abnormal cerebellar cortex morphology ( J:122560 )

• RTN3 immunoreactive dystrophic neurites (RIDNs) are not observed in cortical regions at early ages but are evident at 12-14 months of age

abnormal neurite morphology ( J:122560 )

• abnormal neuritic swelling is observed in the CA1 hippocampal region

• various types of neuronal elements (including myelinated axons and axonal synapses) contain prototfibril-like accumulations which are about 20 nm thick and unbranched; the accumulations are mainly found in membrane-enclosed structures 3-5 um in size

• membrane-enclosed structures contain some synaptic vesicles

abnormal excitatory postsynaptic potential ( J:122560 )

• mean fEPSP (filed excitatory postsynaptic potentials) in stimulated hippocampal slices is significantly lower than in control slices

reduced long-term potentiation ( J:122560 )

• low frequency stimulation of the Schaffer collateral fibers in hippocampal slices produces some short term potentiation but return to baseline in 10 minutes, while in control slices a long term potentiation (LTP) lasting >30 minutes is induced