Analysis Tools
vision/eye
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• mice exhibit ectropion uveae unlike wild-type mice
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• Background Sensitivity: mice exhibit small, white, circular, and usually unilateral lesions in the anterior chamber derived from the lens cortex unlike in wild-type mice or mice on a C57BL/6 congenic background
• 15 of 51 mice older than 3 weeks of age exhibit anterior chamber lens cortex material unlike wild-type mice
• anterior chambers contain cortical lens fragments floating in the aqueous humor unlike in wild-type mice
• lens capsule and lens epithelial cells are absent unlike in wild-type mice
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• the anterior chamber is abnormally deep compared to in wild-type mice
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• by P33
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• at P3, mice exhibit anterior lens vacuolization unlike in wild-type mice
• at P24, all mice exhibit extensive lens cortex vacuolation unlike in wild-type mice
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• at P3, some mice exhibit liquefaction of lens cortical fibers unlike in wild-type mice
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• mice exhibit a small pigmented pre-retinal membrane overlying the optic nerve unlike in wild-type mice
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• mild to moderate retinal ganglion cell loss
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nervous system
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• mild to moderate retinal ganglion cell loss
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