Phenotypes associated with this allele

• Allele Symbol: Foxd1^{tm1(GFP/cre)Amc}
• Allele Name: targeted mutation 1, Andrew P McMahon
• Allele ID: MGI:4359653
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Col1a1^tm2(tetO-LIN28B)Gqda/Col1a1^+ Foxd1^tm1(GFP/cre)Amc/Foxd1^+ Gt(ROSA)26Sor^tm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5638869
cn2	Tg(EIF1AX-Lin28a)#Gqda/0 Foxd1^tm1(GFP/cre)Amc/Foxd1^+	involves: 129S4/SvJae * C57BL/6	MGI:5638871
cn3	Foxd1^tm1(GFP/cre)Amc/Foxd1^+ Nudt21^tm1.1Ejwpj/Nudt21^tm1.1Ejwpj	involves: 129S4/SvJae * C57BL/6	MGI:6386379

Genotype
MGI:5638869

cn1

• Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1⁺; Foxd1^{tm1(GFP/cre)Amc}/Foxd1⁺; Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

hydronephrosis ( J:211179 )

• mice develop hydronephrosis following doxycycline induction

neoplasm

neoplasm ( J:211179 )

N • mice do not develop renal tumors following doxycycline induction

Genotype
MGI:5638871

cn2

• Allelic Composition: Tg(EIF1AX-Lin28a)#Gqda/0; Foxd1^{tm1(GFP/cre)Amc}/Foxd1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

neoplasm

neoplasm ( J:211179 )

N • mice do not develop renal tumors

Genotype
MGI:6386379

cn3

• Allelic Composition: Foxd1^{tm1(GFP/cre)Amc}/Foxd1⁺; Nudt21^tm1.1Ejwpj/Nudt21^tm1.1Ejwpj
• Genetic Background: involves: 129S4/SvJae * C57BL/6

homeostasis/metabolism

increased susceptibility to injury ( J:283035 )

• bleomycin-treated mice once or repeatedly exhibit increased lung fibrosis compared with wild-type mice

• however, no increase in lethality is observed

respiratory system

pulmonary fibrosis ( J:283035 )

• increased in bleomycin-treated mice once or repeatedly