All Phenotypes App<tm1.2Zhe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

App^tm1.2Zhe
targeted mutation 1.2, Hui Zheng
MGI:4359012

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm2.1Zhe	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:4838052
cx2	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm1.2Zhe	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4359074

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm2.1Zhe
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (30 available)
App^tm1.2Zhe mutation (0 available); any App mutation (89 available)
App^tm2.1Zhe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:165417 )

• most homozygotes die by 21 days of age

• born in normal numbers

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm1.2Zhe
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:152457 )

• at E16.5, endplate band width and number are increased compared to in wild-type mice

• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice

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