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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pbsn-ERG*)1Vv
transgene insertion 1, Valeri Vasioukhin
MGI:4358243
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Pbsn-ERG*)1Vv/0 involves: 129S1/SvImJ * C57BL/6J * CBA MGI:5705650
tg2
Tg(Pbsn-ERG*)1Vv/0 involves: 129/Sv * C57BL/6J * CBA MGI:4358248


Genotype
MGI:5705650
tg1
Allelic
Composition
Tg(Pbsn-ERG*)1Vv/0
Genetic
Background
involves: 129S1/SvImJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-ERG*)1Vv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• about 50% of mice 2 years of age and older develop prostate tumors
• tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors
• adenocarcinomas are composed primarily of luminal cells although small numbers of basal cells are seen close to the margins of the tumors

reproductive system
• about 50% of mice 2 years of age and older develop prostate tumors
• tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors
• adenocarcinomas are composed primarily of luminal cells although small numbers of basal cells are seen close to the margins of the tumors

mortality/aging
• shorter lifespan than wild-type mice, with mice beginning to die before 20 months of age and none surviving beyond 35 months of age

neoplasm
• about 50% of mice 2 years of age and older develop prostate tumors
• tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors
• adenocarcinomas are composed primarily of luminal cells although small numbers of basal cells are seen close to the margins of the tumors




Genotype
MGI:4358248
tg2
Allelic
Composition
Tg(Pbsn-ERG*)1Vv/0
Genetic
Background
involves: 129/Sv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-ERG*)1Vv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization
• number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age

endocrine/exocrine glands
• basal cells are surrounded by abnormally accumulating luminal cells and become displaced away from the stromal cell compartment; direct contact between luminal cells and the basement membrane is observed by electron microscopy
• ratio of basal cells to total prostate epithelial cells is significantly decreased compared to controls
• epithelial compartment exhibits a small but significant increase in proportion of proliferating cells compared to controls
• by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization
• number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age

reproductive system
• basal cells are surrounded by abnormally accumulating luminal cells and become displaced away from the stromal cell compartment; direct contact between luminal cells and the basement membrane is observed by electron microscopy
• ratio of basal cells to total prostate epithelial cells is significantly decreased compared to controls
• epithelial compartment exhibits a small but significant increase in proportion of proliferating cells compared to controls
• by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization
• number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory