Mouse Genome Informatics
hm1
    Lrrk2tm1Arte/Lrrk2tm1Arte
involves: C57BL/6N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• DCX+ hippocampal neuroblasts in the adult dentate gyrus
• increased density of early and intermediate DCX+ neuroblasts in the adult dentate gyrus
• however, mice exhibit normal numbers of late neuroblasts
• increased volume of the supra-pyramidal and intra-infra-pyramidal mossy fiber projections
• however, mice exhibit normal volume of Hilar mossy fibers
• increased dendritic length, branching and complexity of young immature neurons in the adult dentate gyrus

cellular
• DCX+ hippocampal neuroblasts in the adult dentate gyrus
• increased density of early and intermediate DCX+ neuroblasts in the adult dentate gyrus
• however, mice exhibit normal numbers of late neuroblasts