All Phenotypes Del(7Ipw-Snord116)1Jbro MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Del(7Ipw-Snord116)1Jbro
deletion, chr 7, Jurgen Brosius 1
MGI:4356431

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(7Ipw-Snord116)1Jbro/Del(7Ipw-Snord116)1Jbro	involves: 129S7/SvEvBrd * C57BL/6	MGI:4356438
ht2	Del(7Ipw-Snord116)1Jbro/+	B6.129S7-Del(7Ipw-Snord116)1Jbro	MGI:4356439
ht3	Del(7Ipw-Snord116)1Jbro/+	involves: 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:4356441
ht4	Del(7Ipw-Snord116)1Jbro/+	involves: 129S7/SvEvBrd * C57BL/6	MGI:4356437
ht5	Del(7Ipw-Snord116)1Jbro/+	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:4356440

Allelic Composition	Del(7Ipw-Snord116)1Jbro/Del(7Ipw-Snord116)1Jbro
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:242655 )

• in the peak procedure task, when anticipating an event, mutants start responding later than controls, and when terminating the behavior, mutants stop earlier, indicating that mutants use different strategies to time their behavior

• in the switch task test, mutants enhance their performance by delaying the switching from one location to the other during both the light and dark phase, resulting in a reduction of the error rate and indicating altered risk assessment in decision making

• however, time perception is normal

abnormal eating behavior ( J:242655 )

• mice subjected to a timed food schedule in constant darkness significantly postpone their food anticipatory activity compared to controls

increased food intake ( J:242655 )

• overall food intake is increased

growth/size/body

postnatal growth retardation ( J:152022 )

Allelic Composition	Del(7Ipw-Snord116)1Jbro/+
Genetic Background	B6.129S7-Del(7Ipw-Snord116)1Jbro

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:152022 )

• when this allele is inherited paternally

postnatal growth retardation ( J:152022 )

• when this allele is inherited paternally

Allelic Composition	Del(7Ipw-Snord116)1Jbro/+
Genetic Background	involves: 129S7/SvEvBrd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:152022 )

growth/size/body

decreased body weight ( J:152022 )

• when this allele is inherited paternally

postnatal growth retardation ( J:152022 )

• when this allele is inherited paternally

Allelic Composition	Del(7Ipw-Snord116)1Jbro/+
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:242655 )

• in the peak procedure task, when anticipating an event, mutants in which the allele is paternally inherited, start responding later than controls, and when terminating the behavior, mutants stop earlier, indicating that mutants use different strategies to time their behavior

• in the switch task test, mutants in which the allele is paternally inherited, enhance their performance by delaying the switching from one location to the other during the light phase, resulting in a reduction of the error rate and indicating altered risk assessment in decision making

• however, time perception is normal

abnormal eating behavior ( J:242655 )

• when the allele is inherited paternally, mice subjected to a timed food schedule in constant darkness significantly postpone their food anticipatory activity compared to controls

increased food intake ( J:242655 )

• overall food intake is increased in mice when the allele is inherited paternally

mortality/aging

postnatal lethality ( J:152022 )

• Background Sensitivity: when this allele is inherited paternally, 15% of mice die during the postnatal period unlike when the background includes FVB/N

cellular

maternal imprinting ( J:242655 )

• the maternal allele is imprinted and silenced

growth/size/body

decreased body weight ( J:152022 )

• when this allele is inherited paternally but not maternally

postnatal growth retardation ( J:152022 )

• by P5 or P6 when this allele is inherited paternally

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:242655

Allelic Composition	Del(7Ipw-Snord116)1Jbro/+
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:152022 )

N	• mice exhibit normal postnatal survival

growth/size/body

decreased body weight ( J:152022 )

• when this allele is inherited paternally

postnatal growth retardation ( J:152022 )

• when this allele is inherited paternally

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