Phenotypes associated with this allele

• Allele Symbol: Klk4^tm1.1Jpsi
• Allele Name: targeted mutation 1.1, James P Simmer
• Allele ID: MGI:4355346
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klk4^tm1.1Jpsi/Klk4^tm1.1Jpsi	involves: Black Swiss * C57BL/6	MGI:4355414

Genotype
MGI:4355414

hm1

• Allelic Composition: Klk4^tm1.1Jpsi/Klk4^tm1.1Jpsi
• Genetic Background: involves: Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal dental enamel of Klk4^tm1.1Jpsi/Klk4^tm1.1Jpsi incisors

skeleton

abnormal enamel morphology ( J:151626 )

• the erupted portion of mandibular incisors are chalky white unlike in wild-type mice

• the enamel of all teeth tends to fracture at point of contact with opposing dentition unlike in wild-type mice

• enamel strength is reduced compared to in wild-type mice

• enamel abrades rapidly following weaning despite a soft diet

mortality/aging

premature death ( J:151626 )

• mice often fail to survive to maturity

• however, mice exhibit normal survival when weaning is extended and mice are fed a soft diet

craniofacial

abnormal enamel morphology ( J:151626 )

• the erupted portion of mandibular incisors are chalky white unlike in wild-type mice

• the enamel of all teeth tends to fracture at point of contact with opposing dentition unlike in wild-type mice

• enamel strength is reduced compared to in wild-type mice

• enamel abrades rapidly following weaning despite a soft diet

growth/size/body

abnormal enamel morphology ( J:151626 )

• the erupted portion of mandibular incisors are chalky white unlike in wild-type mice

• the enamel of all teeth tends to fracture at point of contact with opposing dentition unlike in wild-type mice

• enamel strength is reduced compared to in wild-type mice

• enamel abrades rapidly following weaning despite a soft diet

postnatal growth retardation ( J:151626 )

• mice exhibit delayed growth

• however, on a soft diet mice eventually achieve a normal adult body weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:151626 )

N • mice exhibit normal serum levels of calcium, phosphate, magnesium, alanine aminotransferase, and total protein