All Phenotypes Ikzf2<tm1Kast> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ikzf2^tm1Kast
targeted mutation 1, Philippe Kastner
MGI:4355173

Summary

2 genotypes

Allelic Composition	Ikzf2^tm1Kast/Ikzf2^tm1Kast
Genetic Background	B6.129S2-Ikzf2^tm1Kast

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf2^tm1Kast mutation (0 available); any Ikzf2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• all mice die before weaning due to unknown causes

Allelic Composition	Ikzf2^tm1Kast/Ikzf2^tm1Kast
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf2^tm1Kast mutation (0 available); any Ikzf2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• most mice die of unknown causes before weaning age

• mice that survive weaning have a normal life span

• Background Sensitivity: further backcrossing onto the C57BL/6 strain increases percentage of mice that die

growth/size/body

decreased body weight ( J:151553 )

• mice are smaller than controls at 7-8 weeks of age

• as mice age, the weight of male mice normalizes while females continue to weigh less than controls

vision/eye

abnormal eyelid development ( J:151553 )

• mice have abnormal growth of eyelids

narrow eye opening ( J:151553 )

• mice exhibit smaller eye-openings

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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