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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rb1tm2.1Jyjw
targeted mutation 2.1, Jean YJ Wang
MGI:4354271
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rb1tm2.1Jyjw/Rb1tm2.1Jyjw involves: 129 * C57BL/6 MGI:4354283


Genotype
MGI:4354283
hm1
Allelic
Composition
Rb1tm2.1Jyjw/Rb1tm2.1Jyjw
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2.1Jyjw mutation (0 available); any Rb1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• a third of nursing mothers are unable to eject adequate supplies of milk
• another third are only partially able to nurse
• some pups die by two days of age due to insufficient nutrition
• mammary glands have large, dilated ducts containing milk consisted with a defect in milk ejection
• mice have similar lobuloalveolar formation and milk composition as controls
• female mice have a significantly elevated frequency of hyperplastic ducts about 2-fold greater than controls
• branching frequency and overall ductal morphogenesis appeared normal
• mammary glands have hyperplastic growth throughout development
• hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct

homeostasis/metabolism
• embryonic fibroblasts fail to decrease proliferative rate in response to TGF-beta1

integument
• a third of nursing mothers are unable to eject adequate supplies of milk
• another third are only partially able to nurse
• some pups die by two days of age due to insufficient nutrition
• mammary glands have large, dilated ducts containing milk consisted with a defect in milk ejection
• mice have similar lobuloalveolar formation and milk composition as controls
• female mice have a significantly elevated frequency of hyperplastic ducts about 2-fold greater than controls
• branching frequency and overall ductal morphogenesis appeared normal
• mammary glands have hyperplastic growth throughout development
• hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct

behavior/neurological
• a third of nursing mothers are unable to eject adequate supplies of milk
• another third are only partially able to nurse
• some pups die by two days of age due to insufficient nutrition
• mammary glands have large, dilated ducts containing milk consisted with a defect in milk ejection
• mice have similar lobuloalveolar formation and milk composition as controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory