Phenotypes associated with this allele

• Allele Symbol: Cacna2d1^tm1Aschw
• Allele Name: targeted mutation 1, Arnold Schwartz
• Allele ID: MGI:4353680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna2d1^tm1Aschw/Cacna2d1^tm1Aschw	involves: Black Swiss	MGI:4353725

Genotype
MGI:4353725

hm1

• Allelic Composition: Cacna2d1^tm1Aschw/Cacna2d1^tm1Aschw
• Genetic Background: involves: Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:151101 )

• basal contractility and relaxation (+dP/dt and -dP/dt) are significantly decreased compared to controls

muscle

decreased cardiac muscle contractility ( J:151101 )

• basal contractility and relaxation (+dP/dt and -dP/dt) are significantly decreased compared to controls

abnormal muscle electrophysiology ( J:151101 )

• L-type VDCC peak current density is significantly decreased by 45% compared with wild-type

• there is more than 4-fold increase in the half-activation potential for cardiomyocytes

• the voltage dependence and kinetics of L-type Ca²⁺ activation in heart muscle are shifted in a hypopolarizing direction

nervous system

decreased channel response intensity ( J:151101 )

• L-type VDCC peak current density in cardiomyocytes is significantly decreased by 45% compared with wild-type

• voltage-dependent inactivation independent of current amplitude is slower in mutant mice

increased channel response threshold ( J:151101 )

• there is more than 4-fold increase in the half-activation potential for cardiomyocytes

renal/urinary system

distended urinary bladder ( J:151101 )

• males have a tendency for bladder dilatation