Phenotypes associated with this allele

• Allele Symbol: Antxr1^tm1.2Bstc
• Allele Name: targeted mutation 1.2, Brad St Croix
• Allele ID: MGI:4353383
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Antxr1^tm1.2Bstc/Antxr1^tm1.2Bstc	B6.Cg-Antxr1^tm1.2Bstc	MGI:4353403

Genotype
MGI:4353403

hm1

• Allelic Composition: Antxr1^tm1.2Bstc/Antxr1^tm1.2Bstc
• Genetic Background: B6.Cg-Antxr1^tm1.2Bstc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal cranial suture morphology ( J:150947 )

• thickened due to increased extracellular matrix compared to in wild-type mice

long upper incisors ( J:150947 )

• overgrowth of upper incisors

misaligned incisors ( J:150947 )

• incisors are misaligned

abnormal periodontal ligament morphology ( J:150947 )

• the peridontal ligament around the incisors and molars is thickened due to increased extracellular matrix compared to in wild-type mice

abnormal tooth development ( J:150947 )

• tooth overgrowth results from misalignment of incisors and loss of normal abrasion unlike in wild-type mice

• degeneration of the enamel organ associated with dental dysplasia is observed

abnormal enamel organ morphology ( J:150947 )

• degeneration of the enamel organ associated with dental dysplasia is observed

malocclusion ( J:150947 )

• incisor misalignment worsens with age

skeleton

abnormal cranial suture morphology ( J:150947 )

• thickened due to increased extracellular matrix compared to in wild-type mice

long upper incisors ( J:150947 )

• overgrowth of upper incisors

misaligned incisors ( J:150947 )

• incisors are misaligned

abnormal periodontal ligament morphology ( J:150947 )

• the peridontal ligament around the incisors and molars is thickened due to increased extracellular matrix compared to in wild-type mice

abnormal tooth development ( J:150947 )

• tooth overgrowth results from misalignment of incisors and loss of normal abrasion unlike in wild-type mice

• degeneration of the enamel organ associated with dental dysplasia is observed

abnormal enamel organ morphology ( J:150947 )

• degeneration of the enamel organ associated with dental dysplasia is observed

malocclusion ( J:150947 )

• incisor misalignment worsens with age

abnormal long bone metaphysis morphology ( J:150947 )

• the metaphyseal periosteum of the femur is mildly thickened due to increased extracellular matrix

abnormal vertebrae morphology ( J:150947 )

• vertebral periosteal thickening is minimal compared to in wild-type mice

neoplasm

decreased tumor growth/size ( J:150947 )

• transplanted B16 tumors grow slower than in wild-type mice

• however, the growth of transplanted LCC tumors is not statistically different from in wild-type mice and B16 tumor cell proliferation, hypoxia, and apoptosis are normal

reproductive system

abnormal ovary morphology ( J:150947 )

♀ • mice exhibit loose proteinacious extracellular matrix deposits in the ovaries compared with wild-type mice

♀ • however, follicles develop normally

cardiovascular system

cardiovascular system phenotype ( J:150947 )

N • retinal and wound angiogenesis are normal

endocrine/exocrine glands

abnormal ovary morphology ( J:150947 )

♀ • mice exhibit loose proteinacious extracellular matrix deposits in the ovaries compared with wild-type mice

♀ • however, follicles develop normally

growth/size/body

long upper incisors ( J:150947 )

• overgrowth of upper incisors

misaligned incisors ( J:150947 )

• incisors are misaligned

abnormal periodontal ligament morphology ( J:150947 )

• the peridontal ligament around the incisors and molars is thickened due to increased extracellular matrix compared to in wild-type mice

abnormal tooth development ( J:150947 )

• tooth overgrowth results from misalignment of incisors and loss of normal abrasion unlike in wild-type mice

• degeneration of the enamel organ associated with dental dysplasia is observed

abnormal enamel organ morphology ( J:150947 )

• degeneration of the enamel organ associated with dental dysplasia is observed

malocclusion ( J:150947 )

• incisor misalignment worsens with age

cellular

abnormal extracellular matrix morphology ( J:150947 )

• mice exhibit increased extracellular matrix in the several organs, including ovaries, uterus, and skin compared with wild-type mice

• subtle increases in the extracellular matrix are observed in the lamina propria of the stomach, small and large intestines, urinary bladder, cervix, and tongue