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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il2m1
mutation 1
MGI:4352594
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il2m1/Il2m1 MRL/MpJ MGI:4352597


Genotype
MGI:4352597
hm1
Allelic
Composition
Il2m1/Il2m1
Genetic
Background
MRL/MpJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2m1 mutation (8 available); any Il2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• splenocytes stimulated with concanavalin A for 2 days in culture have lower induction of T cell activation markers including CD25 and lower secretion of IL2, lower than normal levels of activation induced cell death by CD3 or FASL crosslinking, and addition of recombinant IL2, derived from the FVB/NJ coding sequence, with concanavalin A to MRL/MpJ splenocytes in culture partially or fully restores activation markers and restores normal activation induced cell death

immune system
• splenocytes stimulated with concanavalin A for 2 days in culture have lower induction of T cell activation markers including CD25 and lower secretion of IL2, lower than normal levels of activation induced cell death by CD3 or FASL crosslinking, and addition of recombinant IL2, derived from the FVB/NJ coding sequence, with concanavalin A to MRL/MpJ splenocytes in culture partially or fully restores activation markers and restores normal activation induced cell death





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory