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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Appl1Gt(RRS819)Byg
gene trap RRS819, BayGenomics
MGI:4332126
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Appl1Gt(RRS819)Byg/Appl1Gt(RRS819)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:5789933


Genotype
MGI:5789933
hm1
Allelic
Composition
Appl1Gt(RRS819)Byg/Appl1Gt(RRS819)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Appl1Gt(RRS819)Byg mutation (0 available); any Appl1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• normal oxygen consumption, respiratory quotient, and insulin, adiponectin, leptin and lipid (cholesterol, HDL, triglyceride, free fatty acid) levels under fed conditions
• significantly higher plasma glucose levels under fasting conditions relative to wild-type controls
• significantly higher plasma insulin levels under fasting conditions relative to wild-type controls
• however, normal plasma insulin levels under fed conditions
• significantly higher core body temperature relative to wild-type controls
• impaired glucose tolerance in glucose tolerance test (GTT)
• significant reduction in hepatic glucose production (HGP) suppression (% of basal HGP) during hyperinsulinemic-euglycemic clamp relative to wild-type controls
• reduced insulin and adiponectin signaling leading to systemic insulin resistance
• impaired insulin tolerance in insulin tolerance test (ITT)
• significant reductions in glucose infusion rate, total glucose disposal, and insulin-mediated suppression of hepatic glucose production during the hyperinsulinemic-euglycemic clamp relative to wild-type controls

behavior/neurological
N
• normal food intake monitored weekly for 24 weeks under normal chow conditions
• significantly increased activity during the dark cycle relative to wild-type controls

adipose tissue
• enhanced UCP-1 expression in brown fat tissues relative to wild-type controls

growth/size/body
N
• normal body weight and percentage tissue weight of body weight under normal chow conditions at 32 weeks of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory