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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Llgl2Gt(XS0846)Wtsi
gene trap XS0846, Wellcome Trust Sanger Institute
MGI:4331862
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Llgl2Gt(XS0846)Wtsi/Llgl2Gt(XS0846)Wtsi B6.129P2-Llgl2Gt(XS0846)Wtsi MGI:5085292


Genotype
MGI:5085292
hm1
Allelic
Composition
Llgl2Gt(XS0846)Wtsi/Llgl2Gt(XS0846)Wtsi
Genetic
Background
B6.129P2-Llgl2Gt(XS0846)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Llgl2Gt(XS0846)Wtsi mutation (0 available); any Llgl2 mutation (281 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• many pups do not survive to weaning
• reducing litter size eliminates postnatal lethality

growth/size/body
• pups that survive past weaning catch up with littermates in size
• significant at E18.5
• first detected at E15.5

embryo
• differences in labyrinth morphology are not dependent on maternal genotype
• a decrease in the surface area of fetal blood vessels at E13.5 and E14.5, but not at E11.5
• increase in fetal lumen size
• increase in the percentage of large maternal lumens and decrease in the percentage of small lumens at E13.5 but not at E11.5
• increase in the size of maternal blood lumens
• significantly decreased in area
• at E11.5 the syncytiotrophoblast layers I and II in the trilaminar layer contain more frequent gaps and openings than in control littermates
• increase in the percentage of large maternal lumens and decrease in the percentage of small lumens at E13.5 but not at E11.5 indicates a defect in branching morphogenesis of villi in the labyrinth layer
• a decrease in the trophoblast transport surface area in the labyrinth at E13.5 and E14.5
• at E11.5 - E14.5
• from E13.5 - E17.5

integument
N
• skin hemidesmosomes and overall skin morphology are normal, unlike in zebrafish with a mutation in this gene

cardiovascular system
• a decrease in the surface area of fetal blood vessels at E13.5 and E14.5, but not at E11.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory