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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vps35Gt(RRK261)Byg
gene trap RRK261, BayGenomics
MGI:4130266
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vps35Gt(RRK261)Byg/Vps35Gt(RRK261)Byg B6.129P2-Vps35Gt(RRK261)Byg MGI:5306776
ht2
Vps35Gt(RRK261)Byg/Vps35+ B6.129P2-Vps35Gt(RRK261)Byg MGI:5695247
cx3
Vps35Gt(RRK261)Byg/Vps35+
Tg(APPSWE)2576Kha/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5306777


Genotype
MGI:5306776
hm1
Allelic
Composition
Vps35Gt(RRK261)Byg/Vps35Gt(RRK261)Byg
Genetic
Background
B6.129P2-Vps35Gt(RRK261)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vps35Gt(RRK261)Byg mutation (1 available); any Vps35 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5695247
ht2
Allelic
Composition
Vps35Gt(RRK261)Byg/Vps35+
Genetic
Background
B6.129P2-Vps35Gt(RRK261)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vps35Gt(RRK261)Byg mutation (1 available); any Vps35 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• rearing frequency is decreased by 35.6% and 82.2% in 12- and 18- month old mice, respectively
• in the open field, total distance and velocity of 12- and 18-month old mice is reduced
• however, performance in the rotarod and gait tests is normal

homeostasis/metabolism
• dopamine levels are reduced in the striatum and ventral midbrain at 6 month or older mutants
• ratios of 3,4-dihydroxyphenylacetic acid (DOPAC)/dopamine or 3,4-dihydroxyphenylacetic acid (HVA)/dopamine are much higher in 12 month old mutant striatum compared to controls
• however, 5-HT levels are normal

nervous system
• dopamine levels are reduced in the striatum and ventral midbrain at 6 month or older mutants
• ratios of 3,4-dihydroxyphenylacetic acid (DOPAC)/dopamine or 3,4-dihydroxyphenylacetic acid (HVA)/dopamine are much higher in 12 month old mutant striatum compared to controls
• however, 5-HT levels are normal
• TH+ neurons exhibit disturbed and decreased fibers/processes in substantia nigra pars compacta of aged mice
• decrease in the number of TH+ neurons in aged (12 months) mice, with an approximate 20% loss of TH+ somas in the substantia nigra pars compacta
• mice show age-dependent accumulation of alpha-synuclein in in substantia nigra pars compacta-dopamine neurons
• both monomeric and oligomeric, or phosphorylated and unphosphorylated, species of alpha-synuclein are increased in mice older than 6 months, with an increase only in the ventral midbrain but not in the hippocampus

cellular
• Lamp1-positive late endosomes/early lysosomes appear enlarged in dopamine neurons
• Lamp2-positive vesicles appear smaller in size in dopamine neurons

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 17; PARK17 614203 J:225806




Genotype
MGI:5306777
cx3
Allelic
Composition
Vps35Gt(RRK261)Byg/Vps35+
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSWE)2576Kha mutation (3 available)
Vps35Gt(RRK261)Byg mutation (1 available); any Vps35 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal paired-pulse facilitation and inhibitory synaptic transmission
• in the hippocampus and cerebral cortex
• greater accumulation than in Tg(APPSWE)2576Kha mice
• accelerated compared to in Tg(APPSWE)2576Kha mice
• field excitatory postsynaptic potential slopes in the CA1 and dentate gyrus are reduced compared to in either single heterozygotes
• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice
• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice
• in the CA1 at 2 months
• worsened at 4 months in the CA1
• however, long term potentiation in the dentate gyrus is normal
• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice
• at 4 months in the CA1

behavior/neurological
• in a Morris water maze, mice exhibit increased latencies to finding the hidden platform and in pathway length compared with either single heterozygote
• deficits increase with age

homeostasis/metabolism
• in the hippocampus and cerebral cortex
• greater accumulation than in Tg(APPSWE)2576Kha mice





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory