nervous system phenotype ( J:178937 )

N	• mice exhibit normal paired-pulse facilitation and inhibitory synaptic transmission (J:178937)

amyloid beta deposits ( J:178937 )

• in the hippocampus and cerebral cortex

• greater accumulation than in Tg(APPSWE)2576Kha mice

impaired synaptic plasticity ( J:178937 )

• accelerated compared to in Tg(APPSWE)2576Kha mice

abnormal excitatory postsynaptic potential ( J:178937 )

• field excitatory postsynaptic potential slopes in the CA1 and dentate gyrus are reduced compared to in either single heterozygotes

reduced AMPA-mediated synaptic currents ( J:178937 )

• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice

reduced NMDA-mediated synaptic currents ( J:178937 )

• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice

reduced long term potentiation ( J:178937 )

• in the CA1 at 2 months

• worsened at 4 months in the CA1

• however, long term potentiation in the dentate gyrus is normal

abnormal miniature excitatory postsynaptic currents ( J:178937 )

• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice

decreased post-tetanic potentiation ( J:178937 )

• at 4 months in the CA1

abnormal spatial learning ( J:178937 )

• in a Morris water maze, mice exhibit increased latencies to finding the hidden platform and in pathway length compared with either single heterozygote

• deficits increase with age

amyloid beta deposits ( J:178937 )

• in the hippocampus and cerebral cortex

• greater accumulation than in Tg(APPSWE)2576Kha mice