Mouse Genome Informatics
hm1
    Vps35Gt(RRK261)Byg/Vps35Gt(RRK261)Byg
B6.129P2-Vps35Gt(RRK261)Byg
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die prior to E10


Mouse Genome Informatics
cx2
    Vps35Gt(RRK261)Byg/Vps35+
Tg(APPSWE)2576Kha/0

involves: 129P2/OlaHsd * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• mice exhibit normal paired-pulse facilitation and inhibitory synaptic transmission (J:178937)
• in the hippocampus and cerebral cortex
• greater accumulation than in Tg(APPSWE)2576Kha mice
• accelerated compared to in Tg(APPSWE)2576Kha mice
• field excitatory postsynaptic potential slopes in the CA1 and dentate gyrus are reduced compared to in either single heterozygotes
• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice
• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice
• in the CA1 at 2 months
• worsened at 4 months in the CA1
• however, long term potentiation in the dentate gyrus is normal
• mice exhibit reduced AMPA and NMDA receptor-mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons compared with control mice
• at 4 months in the CA1

behavior/neurological
• in a Morris water maze, mice exhibit increased latencies to finding the hidden platform and in pathway length compared with either single heterozygote
• deficits increase with age

homeostasis/metabolism
• in the hippocampus and cerebral cortex
• greater accumulation than in Tg(APPSWE)2576Kha mice