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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mirc35hgGt(D016D06)Wrst
gene trap D016D06, German Gene Trap Consortium
MGI:3881348
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mirc35hgGt(D016D06)Wrst/Mirc35hgGt(D016D06)Wrst involves: 129S2/SvPas * C57BL/6J MGI:5478599


Genotype
MGI:5478599
hm1
Allelic
Composition
Mirc35hgGt(D016D06)Wrst/Mirc35hgGt(D016D06)Wrst
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Progressive retinal degeneration and increased susceptibility to light damage in Mirc35hgGt(D016D06)Wrst/Mirc35hgGt(D016D06)Wrst mice

vision/eye
• expression analysis indicates abnormalities in synaptic ribbons as early as 5 weeks of age that become more severe with age
• ribbon size is reduced
• number and size of cone pedicles appear to be decreased at 5 weeks of age and this decrease progresses with age
• decrease in the number of M opsin+ cones in the superior retina
• progressive thinning starting at 6 months of age
• thickness is reduced by about 30% in the superior retina at 6 months of age but no change is detected in the inferior retina
• by 1 year of age the entire retina is affected
• progressive retinal degeneration starting by 6 months of age, with the super retina more affected than the inferior retina
• decrease in the b wave amplitude in mice at 5 weeks, 6 months and 1 year of age
• abnormalities progress with age and more severely affect photopic b wave amplitudes compared to scotopic b waves
• at 1 year of age, the b wave amplitude is less than 10% that of wild-type control littermates
• a-wave amplitudes decrease with age starting after 5 weeks of age and the photopic response decreases more rapidly than the scotopic response
• at 6 months and 1 year of age, the a wave amplitude is 40% and less than 10% that of controls, respectively
• latency (time from onset of stimulus to beginning of the a wave) and implicit time (time from the onset of light stimulus to the peak of the b wave) are increased from 6 months of age on
• decrease in the b wave amplitude in mice at 5 weeks, 6 months and 1 year of age
• abnormalities progress with age and more severely affect photopic b wave amplitudes compared to scotopic b waves
• a-wave amplitudes decrease with age starting after 1 year of age, when it is decreased 43-56% of control, and the photopic response decreases more rapidly than the scotopic response
• latency (time from onset of stimulus to beginning of the a wave) and implicit time (time from the onset of light stimulus to the peak of the b wave) are increased from 6 months of age on

growth/size/body
• decreased by about 24% compared to controls

behavior/neurological
• unstable gait
• unstable gait
• develops as early as 4 weeks of age

homeostasis/metabolism
• increase in the sensitivity of retina to light damage
• exposure to 10,000-lx cool, white fluorescent light for 2 h followed by 2 weeks in the dark results in increased loss of nuclear layers in the ONL with the superior retina showing more damage than the inferior retina

nervous system
• expression analysis indicates abnormalities in synaptic ribbons as early as 5 weeks of age that become more severe with age
• ribbon size is reduced
• number and size of cone pedicles appear to be decreased at 5 weeks of age and this decrease progresses with age
• decrease in the number of M opsin+ cones in the superior retina
• expression analysis indicates abnormalities in photoreceptor synaptic ribbons as early as 5 weeks of age that become more severe with age
• photoreceptor synaptic ribbon size is reduced

integument
• increase in the sensitivity of retina to light damage
• exposure to 10,000-lx cool, white fluorescent light for 2 h followed by 2 weeks in the dark results in increased loss of nuclear layers in the ONL with the superior retina showing more damage than the inferior retina





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory